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《Chongqing Medicine》 2017-18
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Preemptive analgesic effect of administration timing of parecoxib sodium in patients with total hip arthroplasty

Zhang Hui;Chen Jun;Chen Shuai;Zhang Hua;Li Yulin;Tang Yi;Department of Orthopedics,Jianyang Municipal People′s Hospital;Department of Orthopedics,First Affiliated Hospital of Chongqing Medical University;  
Objective To investigate the clinical preemptive analgesic efficacy of parecoxib sodium(PS)at different administration timing in the patients with total hip arthroplasty(THA).Methods Sixty patients receiving THA were prospectively enrolled and randomized into three groups.The group A started to be intravenously injected by PS 40mg/d on preoperative 3duntil operation day;the group B was intravenously injected by parecoxib sodium 40 mg at preoperative 30min;the group C began to be intravenously injected by the same dosage of normal saline at the same time point as the group A.The rest pain was assessed by using the visual analog scale(VAS)at postoperative 6,24,48,72 h.The duration of patient-controlled intravenous analgesia(PCIA)and total dosage were recorded.The first time unaided ambulation time was observed.Results The VAS scores at various postoperative time points in the group A and B were significantly lower than those in the group C(P0.05),the VAS scores at postoperative 6,24 hin the group A were remarkably lower than those in the group B.The PCIA duration in the group A,B and C were 25.05±10.32),(36.75±13.91),(50.40±15.17)h,respectively,the pair-wise comparison of the group A,B and C showed statistical difference(P0.05).The total dosages of PCIA drug in the group A,B and C were(29.25±4.58),(34.50±5.09),(62.65±10.52)μg,respectively,the dosage in the group A and B was significantly lower than that in the group C(P0.05).The first time unaided ambulation time in the group A,B and C were(2.75±0.81),(3.05±1.08),(4.10±0.92)d respectively,which in the group A and B was earlier than that in the group C(P0.05).Conclusion Continuously using PS on preoperative 3dcan increase the analgesic effect in THA patients and is conducive to the functional rehabilitation and increase the patient satisfaction.
【CateGory Index】: R687.4
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN Wei;LI Wei;XIE Dong-wu;RAO Qing;WANG Jian;Department of Anesthesiology, Mianyang Central Hospital;;Effects of Parecoxib Sodium Preemptive Analgesia on Postoperative Inflammatory Cytokines and Stress Responses in Elderly Patients Undergoing Total Hip Replacement[J];华西医学;2015-06
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【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Zhang Hui;Chen Jun;Chen Shuai;Zhang Hua;Li Yulin;Tang Yi;Department of Orthopedics,Jianyang Municipal People′s Hospital;Department of Orthopedics,First Affiliated Hospital of Chongqing Medical University;;Preemptive analgesic effect of administration timing of parecoxib sodium in patients with total hip arthroplasty[J];重庆医学;2017-18
2 ZHENG Li;LIU Lianxin;SUN Dan;WANG Ling;Department of Liver Surgery,the First Clinical Hospital Affiliated to Harbin Medical University;;Influence of early rapid rehabilitation nursing on postoperative rehabilitation and quality life in patients with primary liver cancer resection[J];中国医药导报;2016-34
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