Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2017-20
Add to Favorite Get Latest Update

Clinical significance of peripheral blood Th17 cells and their cytokines in tongue squamous cell carcinoma

Li Yanbo;He Zhiliang;Su Danni;Wang Chengyang;He Chenggong;Cao Lei;Department of Stomatology,Chengde Municipal Central Hospital;Operation Room,Chengde Municipal Central Hospital;  
Objective To investigate the clinical significance of peripheral blood Th17 cells and their cytokines in the patients with tongue squamous cell carcinoma.Methods Sixty-six cases of tongue squamous cell carcinoma in our hospital from January2013 to January 2016 served as the research subjects and contemporaneous 42 volunteers undergoing healthy physical examination were selected as the control group.Peripheral blood was collected in all subjects.The proportion of peripheral blood Th17 cells was detected by flow cytometry.The IL-17,TGF-βand IL-6cytokine levels were detected by ELISA.Results The proportion of peripheral blood Th17 cells,IL-17,TGF-βand IL-6in the observation group and the control group were(1.46±0.41)% vs.(0.31±0.12)%,(123.36±21.20)pg/mL vs.(20.76±8.95)pg/mL,(215.80±21.52)pg/mL vs.(26.90±10.41)pg/mL,(17.32±8.02)pg/mL vs.(5.85±1.49)pg/mL respectively,the differences were statistically significant(P0.05).The proportion of peripheral blood Th17 cells,IL-17,TGF-βand IL-6levels were increased with the increase of tongue squamous cell carcinoma clinical stage(P0.01).The TGF-βlevel was positively correlated with the IL-17level(r=0.626,P=0.021),the IL-6level was positively correlated with the proportion of Th17 cells and IL-17(r=0.626,0.597,P=0.021,0.034).Conclusion The increase of Th17 cells and IL-17 expression plays an important role in the development and progression of tongue squamous cell carcinoma,Th17 cells and IL-17 cytokine can become the important target spots of anti-tumor therapy.
【Fund】: 2013年承德市科学技术研究与发展计划项目(2013201)
【CateGory Index】: R739.86
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved