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《Chongqing Medicine》 2017-20
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Infiltration and effect of CD68~+ and CD163~+ macrophages in oral squamous cell carcinoma

Li Shumei;Feng Hongchao;Ma Zhujun;Wei Jing;Department of Oral and Maxillofacial Surgery,Guizhou Medical University;Department of Oral and Maxillofacial Surgery,Guiyang Municipal Stomatological Hospital;  
Objective To investigate the correlation between the number of CD68~+ and CD163~+ macrophages infiltration and the clinical characteristics of oral squamous cell carcinoma(OSCC),and to investigate the role and significance of CD163~+and CD68~+ macrophages in OSCC.Methods Forty-two cases of OSCC resected by operation and diagnosed by postoperative pathology with intact clinical data in our hospitals during 2013-2016 were selected.Other 12 cases of oral mamaxillofacial normal tissue served as controls.The number of CD68~+ and CD163~+macrophages infiltration in OSCC was detected by immunohistochemistry.Its correlation with clinical characteristics was analyzed.Results The number of CD68~+ and CD163~+macrophages infiltration in OSCC was significantly higher than that in the control group(P0.05);the infiltration quantity of CD68~+ and CD163~+macrophages in poor differentiation and moderate differentiation was significantly higher than that in high differentiation(P0.05).The number of CD68~+ macrophages in lymph node metastasis was significantly lower than that without lymph node metastasis(P0.05).The number of CD163~+ macrophages in the lymph node metastasis was significantly higher than that of CD68~+(P0.05).The number of CD68~+ and CD163~+ macrophages had positive correlation in OSCC(r=0.48,P=0.00).Conclusion Tumor-associated macrophages(TAMs)and M2 macrophages may play an important role in OSCC,TAMs may inhibits lymph node metastasis in OSCC,while M2 marcophages may promote the lymphatic matastasis of OSCC.
【Fund】: 贵阳市卫生局科学技术计划项目([2014]筑卫科技合同字第15号)
【CateGory Index】: R739.8
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