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《Chongqing Medicine》 2017-20
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Analysis on pathological changes of portal vein and hepatic artery in patient with cirrhotic portal hypertension

Zhang Hao;Li Bo;Department of Hepatopancreatobiliary Surgey,Sichuan Provincial People′s Hospital;Department of Liver Surgery,West China Medicial Center,Sichuan University;  
Objective To research the tissue structure changes of vessels wall in the patients with liver cirrhotic portal hypertension and to investigate the role of inducible nitric oxide synthase(iNOS)in development process of liver cirrhosis.MethodsThe left portal vein,left hepatic artery and left hepatic vein(n=27)were collected from the patients with liver transplantation as the case group and the corresponding vessels of traumatic hepatectomy were collected as control group(n=15).HE staining and Masson staining were performed respectively.The hepatic arteries were stained with elastic fibers and immunized with anti-human iNOS polyclonal antibody.Results Compared with the control group,the portal vein intima and tunica media in the case group were thickened,the smooth muscle cells of tunica media were hyperplasia and hypertrophy,partial smooth muscle cells protruded into the intima;the irregular proliferation of hepatic arterial intima,arterial luminal stenosis,internal elastic membrane flatten,and even fracture,the tunica media smooth muscle hyperplasia to the intima were also observed;no obvious structural changes were observed in the hepatic vein wall.The higher expression of iNOS was found in the cytoplasm of hepatic artery smooth muscle cells(P0.01).Conclusion The walls of liver artery and portal vein in the patients with liver cirrhosis would secondarily develop the tissue structure reconstruction,which is the results of human body′s own compensatory mechanism,the higher expression of iNOS accelerats the occurrence and development of the tissue structure reconstruction.
【CateGory Index】: R575.2
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