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《Chongqing Medicine》 2017-20
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Comparison of short-term curative effects of prucalopride and mosapride respectively combined with low dose polyethylene glycol in treating elderly refractory functional constipation

Huang Haihui;Zhang Xiaomin;Zhao Liang;Department of Gastroenterology,Yuancheng District People′s Hospital;  
Objective To compare the short-term curative effects of prucalopride and mosapride respectively combined with low dose polyethylene glycol in treating elderly refractory functional constipation.Methods Ninety patients with elderly refractory functional constipation in the outpatient department of our hospital from May 2014 to February 2016 were retrospectively analyzed and divided into two groups randomly,45 cases in each group.the prucalopride group:Prucalopride Succinate Tablets,2mg,4times daily;the mosapride group:Mosapride Citrate Capsules,5mg,3times daily.Polyethylene Glycol Electrolytes Powder(PEG)was also used in the two groups,13.125 g,twice daily.The course of treatment was 4 weeks.The first defecating time and defecation difficulty relief time,average weekly spontaneous complete bowel movements(SCBM),defecating difficulty,stool character,adverse reactions and change of life quality were observed in the two groups.Results The treatment effective rate of slow transit constipation(STC)and defecatory disorder had the statistical difference between the two groups(P0.05).The comparison of the effective rates in mixed type showed no statistical difference between the two groups(P0.05).Compared with the mosapride group,the first defecating time and defecation difficulty relief time in the prucalopride group were shorter with statistical difference(P0.05).After 4-week treatment,SCBM times per week in the two groups were more than 3times;the times of the prucalopride group were even more.In the prucalopride group,the defecation difficulty improvement was more obvious,the difference between the two groups had statistical significance(P0.05).As for the comparison of the stool character improvement,the difference had no statistical significance(P0.05).The total effective rate had statistical difference between the two groups(P0.05).The incidence rate of adverse reactions had no statistical difference between the two groups(17.78%vs.15.56%,P0.05).The total average score of PAC-QOL after treatment in the two groups were both decreased,moreover the decrease in the prucalopride group was more obvious;the difference between the two groups had statistical significance(P0.05).Conclusion Prucalopride +PEG take effect faster in the treatment of elderly refractory functional constipation and has the advantages in the aspects of overall curative effect and life quality improvement,which is specially suitable for STC and defecatory disorder type.
【CateGory Index】: R574.62
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