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《Chongqing Medicine》 2017-21
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An experimental study of magnetic resonance DTI quantitative evaluation on effect of Mailuoning Injection for non-compressive lumbar radiculitis

Peng Tao;Niu Xiangke;Xiao Jianming;Wang Zongyong;Zhi Biao;Yang Chaobing;Chen Yuntao;Yang Xi;Han Lixin;Department of Radiology,Affiliated Hospital of Chengdu University;  
Objective To investigate use of magnetic resonance diffusion tensor imaging(MR-DTI)for quantitatively evaluating the efficacy of Mailuoning Injection on non-compressive lumbar radiculitis.Methods Nine Bama mini pigs were selected and divided into group A,B and C,3 cases in each group.The non-compressive lumbar radiculitis model was established under CT-guiding.The corresponding therapeutic drugs(group A:10 mL Mailuoning;group B:10 mL normal saline;group C:10 mL diminishing inflammation fluid)were given by epidural injection on 14 d after constructing model.MR-DTI was performed before model construction,14 d after model construction and before treatment.One experimental pig in each group was taken on 3,7,14 d after treatment,performed MR-DTI and killed for taking the nerve root sample to conduct the immunohistochemical detection.The fractional anisotropy(FA)values of nerve root in MR-DTI imaging were measured.The FA values and immunohistochemical detection results were statistically analyzed.Results MR-DTI:the FA values after model construction in each group was decreased(P0.05);the FA values on 14 d after treatment in the group A was increased,which showed statistically significant difference compared with before treatment(P0.05);the FA values after 3,7 d treatment in the group A had no obvious increase,the difference between the group A and B was not statistically significant(P0.05),but the FA values increase in the group C was earlier and more rapid than other two groups(P0.05);the FA values after 14 d treatment in the group A was risen again,the FA values of bilateral nerve roots had no statistical difference between the group A with the group B and C(P0.05),while the FA values had statistical difference between the group B and C(P0.05).The immunohistochemical results:TNF-αintegral absorbency value(IA value)on 7 d after treatment in the group A began to decline;the TNF-αIAvalue on 14 d after treatment in the group A and C was significantly decreased compared to group B,the difference was statistically significant(P0.05).Conclusion Mailuoning Injection has a certain effect on non-compressive lumbar radiculitis,which can be evaluated by using DTI.
【Fund】: 四川省医学科研青年创新课题计划项目(Q14004)
【CateGory Index】: R445.2;R681
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