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《Chongqing Medicine》 2017-21
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Effect evaluation of 2% anisodamine cream in preventing chemotherapy phlebitis caused by 5-fluorouracil

Liu Dan;Liao Jinlian;Gao Wen;Wei Yiping;Liao Haitao;College of Nursing,Guangxi Medical University;Department of Radiotherapy,the First Affiliated Hospital of Guangxi Medical University;  
Objective To explore the interventional effect of two different methods in the prevention of chemotherapy phlebitis caused by 5-fluorouracil.Methods Eighty cases of patients treated with cisplatin+5-fluorouracil(PF)chemotherapy in the First Affiliated Hospital of Guangxi Medical University from May 2015 to July 2016 were selected and divided into the observation group and control group according to admission time,40 cases in each group.The observation group was smeared with 2% anisodamine along the direction of vein puncture after peripheral venous puncture success,while the control group was smeared with mucopolysaccharide polysulphate emulsion paste.The occurrence of phlebitis and degree of local pain after intervention were compared between the two groups.The blood biochemical indexes and inflammatory factors levels before and after intervention were compared too.Results After the intervention,the distribution of phlebitis level and local pain degree had statistical difference between the two groups(Z=2.57,2.53;P=0.01);the observation group was superior to the control group in the aspects of phlebitis lesion degree and local pain alleviation;WBC,MPV and PDW in the observation group had statistical difference between before and after intervention;WBC,PLT and PCT in the control group had statistical difference between before and after intervention(P0.05);PLT count was positively correlated with PCT in the two groups(r=0.952,P0.05);the CRP level and WBC count after intervention had no statistical difference between the two groups(P0.05).Conclusion 2% anisodamine can effectively prevent and alleviate the occurrence of 5-FU caused chemotherapy phlebitis and local pain.At the same time,PLT can provide a basis for preventing chemotherapy phlebitis.
【Fund】: 国家自然科学基金资助项目(81260290);; 广西卫生厅广西医疗卫生重点科研项目(重2012113);; 广西自然科学基金资助项目(2013GXNSFAA019188)
【CateGory Index】: R473.73
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