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《Chongqing Medicine》 2017-21
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Anti-HBc levels in patients with different natural history of chronic HBV infection and cirrhosis and its clinical significance

Cao Hongting;Yao Shangyan;Luo Haibo;Liu Yunzhou;Li Jianye;Wu Yingsong;Institute of Antibody Engineering,School of Laboratory Medicine and Biotechnology,Southern Medical University;Department of Clinical Laboratory,421 Hospital of PLA;  
Objective To investigate the serum anti-HBc level in patients with different natural history of chronic hepatitis B virus(HBV)infection and cirrhosis, and its clinical value for distinguishing the natural history statue.Methods A total of 160 patients with chronic HBV infection from March 2015 to June 2016 were enrolled, and they were divided into immune tolerance group(n=43),HBeAg-positive chronic hepatitis B(CHB)group(n=37),inactive carrier group(n=39) and HBeAg-negative CHB group(n=41).A total of 44 patients with HBeAg-positive cirrhosis and 46 patients with HBeAg-negative cirrhosis were enrolled too.The general conditions data were collected, and HBsAg,HBeAg,anti-HBc,HBV DNA load and HBV genotype were detected.The associations between anti-HBc level and clinical parameters were analyzed, and the diagnostic value of anti-HBc for distinguishing different natural histories was analyzed.Results The anti-HBc levels in different natural history from high to low were as following:HBeAg-positive CHB group(4.22±0.68)log_(10)IU/ mL,HBeAg-negative CHB group(3.89±0.88)log_(10)IU/ mL,inactive carrier group(3.07±0.68)log_(10)IU/ mL and immune tolerance group(2.88±0.82)log_(10)IU/ mL.The anti-HBc levels in HBeAgpositive and HBeAg-negative cirrhosis patients were(3.04±0.82)and(3.15±0.86)log_(10)IU/ mL,respectively.In HBeAg-positive CHB group,the anti-HBc was positively associated with ALT(r=0.353,P=0.032) and AST(r=0.421,P=0.009).In HBeAg-negative CHB group,the anti-HBc was positively associated with HBV DNA(r=0.343,P=0.028),ALT(r=0.458,P=0.003) and AST(r=0.495,P=0.001).The AUC of anti-HBc used to distinguish immune tolerance from HBeAg-positive CHB was 0.903, and the AUC used to distinguish inactive carrier from HBeAg-negative CHB was 0.833.Conclusion Anti-HBc levels in different natural history of chronic HBV infection are significantly different, and anti-HBc could be used to distinguish the natural history statue of chronic HBV infection with a higher diagnostic value than HBsAg.
【Fund】: 国家自然科学基金资助项目(81271931)
【CateGory Index】: R512.62;R575.2
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