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《Chongqing Medicine》 2017-21
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Study on drug resistance status of Helicobacter pylori in patients with chronic obstructive pulmonary disease

Zhou Gang;Hu Yi;Zhao Zhengzhong;Department of Gastroenterology,Jiangjin District Central Hospital;  
Objective To study the resistance status of helicobacter pylori(HP)to commonly used antibacterial drugs as well as clinical effects of quadruple therapy in the patients with chronic obstructive pulmonary disease(COPD)infected by Hp.Methods A total of 180 cases of patients with Hp infection in the inpatient department and outpatient department of our hospital from August 2012 to December 2014 were collected,including 90 cases of COPD(COPD group) and 90 cases of non-COPD(control group).The gastric antrum mucosal tissues in all cases were taken for conducting Hp culture and identification.The resistance situation to clarithromycin,metronidazole,amoxicillin,levofloxacin and furazolidone in each group was observed.In addition,the two groups were equally divided into subgroup A,B and C according to different medication schemes:which were given 3 kinds of quadruple medication scheme containing amoxicillin and clarithromycin(group A),amoxicillin and levofloxacin(group B) and amoxicillin and furazolidone(group C).Then the clinical effects were compared.Results The resistance rate of infected Hp strains to clarithromycin in the control group was 21.11% ;which to metronidazole was 55.56% ;which to amoxicillin was 3.33% ;which to levofloxacin was 5.56% ,while which in the COPD group were in turn 26.67% ,57.78% ,7.78% and 16.67% respectively.No strain was found to be resistant to furazolidone in the two groups.There was statistically significant difference in the resistance to levofloxacin and double antibiotic resistance between the two groups(P0.05).The eradication rates for using 3 kinds of quadruple therapy in 3 subgroups of control group were 90.0% in the group A,96.7% in the group B and 100.0% in the group C,while which in the COPD group were 86.7% ,80.0% and 96.7% respectively;the Hp eradication rate for adopting the group B scheme had statistical difference between the two groups(P0.05).Conclusion The resistance rate of COPD patient affected by Hp to levofloxacin has an increasing trend,so its use should be cautious.The quadruple scheme containing amoxicillin+furazolidone can serve as the preferred scheme for the initial Hp eradication therapy in COPD patients affected by Hp.
【Fund】: 重庆市卫生局医学科研计划面上项目(2011-2-450)
【CateGory Index】: R563.9
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