Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chongqing Medicine》 2017-21
Add to Favorite Get Latest Update

Clinical curative effect of tripterygium polyglycoside combined with cozaar in elderly patients with IgA nephropathy and its influence on expression of TGF-β1,PAI-1 and VEGF

Fang Hui;Zhang Xuhuan;Zhang Chenjie;Liu Haiyan;Chen Tieji;Ren Qinjie;Cao Jing;Department Nephrology,Jiaxing Hospital of Armed Police Zhejiang Corps;Medical College of Nanchang University;  
Objective To observe the clinical curative effect of tripterygium polyglycoside combined with cozaar in elderly patients with IgA nephropathy(IgAN) and its influence on expressions of TGF-β1,PAI-1 and VEGF.Methods Eighty elderly patients with IgA nephropathy in Jiaxing Hospital of Armed Police Zhejiang Corps from April 2011 to January 2016 were selected and randomly divided into the control group and observation group,40 cases in each group.The two groups received the routine treatment of chronic basic diseases and took oral cozaar.On this basis the observation group took tripterygium polyglycoside for continuous 12 months.Urine protein,serum creatinine(Scr),blood urea nitrogen(BUN),plasma Alb,urine TGF-β1,PAI-1 and VEGF levels before treatment and at 3,6,12 months after treatment were compared between the two groups.The occurrence situation of adverse reactions was recorded.Results The 24 hurinary protein levels at 3,6,12 months after treatment in the two groups were decreased,moreover the 24 hurine protein level at each time point in the observation group was lower than that in the control group,the difference was statistically significant(P0.05).The levels of Scr,BUN,urine TGF-β1,PAI-1 and VEGF after treatment in the two groups were decreased compared with before treatment,while the Alb level was increased compared with before treatment,moreover the levels of Scr,BUN,urine TGF-β1,PAI-1 and VEGF in the observation group were lower than those in the control group,while the Alb level was higher than that in the control group,the difference was statistically significant(P0.05).The observation group appeared 2 cases of leukopenia,1 case of liver dysfunction and no serious adverse reactions occurred.ConclusionTripterygium polyglycoside combined with cozaar has a significant therapeutic effect on elderly patients with IgAN,can significantly reduce urinary protein and protect renal function,moreover its clinical use is safer.Its efficacy may be related to reducing the expression levels of TGF-β1,PAI-1 and VEGF.
【CateGory Index】: R692.31
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 SHEN Shi-zhong;YANG Zhong-min;CAI Jia-ying;HU Yi-yang;XIE Qian-hong;SUN Ling-yun;Department of Nephrology,the First Hospital of Quanzhou, Affiliated to Fujian Medical University;;Efficacy of atorvastatin combined with tripterygium wilfordii glycosides in the treatment of IgA nephropathy[J];中国临床药理学杂志;2015-03
2 XIANG Qiong;SONG En-feng;LIU Hong-yan;Renmin Hospital of Wuhan University;;Efficacy Observation of IgA Nephropathy Treated with Tripterygium Glycosides Tablets and Telmisartan in the Middle and Aged Patients[J];世界中西医结合杂志;2014-07
3 ZHANG Huiru The First Hospital of Shijiazhuang City,Hebei Province,Shijiazhuang 050011,China;Observation on clinical efficacy of Tripterygium Wilfordii with Mycophenolate Mofetil in the treatment of elderly IgA nephropathy[J];中国医药导报;2013-01
4 WU Ping ZHU Chun Department of Nephrology,Xinhua Hospital Affiliated to Shanghai Jiaotong University,Shanghai 200092,China;Observation and exploration of influence of Tripterygium Glycosides on renal function and part TGF-β_1 immune parameters of patients with IgA nepharopathy[J];中国医药导报;2012-28
【Co-citations】
Chinese Journal Full-text Database 7 Hits
1 Fang Hui;Zhang Xuhuan;Zhang Chenjie;Liu Haiyan;Chen Tieji;Ren Qinjie;Cao Jing;Department Nephrology,Jiaxing Hospital of Armed Police Zhejiang Corps;Medical College of Nanchang University;;Clinical curative effect of tripterygium polyglycoside combined with cozaar in elderly patients with IgA nephropathy and its influence on expression of TGF-β1,PAI-1 and VEGF[J];重庆医学;2017-21
2 Lan Hongjuan;Dianbai District People's Hospital in Maoming City;;Clinical Effect of Tripterygium Glycosides Combined with Hormone and Ziyin Yishen Huoxue Decoction Combined with Hormone in the Treatment of IgA Nephropathy[J];数理医药学杂志;2017-05
3 WU Jie;YANG Xiaojun;WANG Jing;LIU Jing;LU Jun;CHENG Lufeng;Department of Pharmacology,School of Bosic Medical Sciences,Xinjiang Medical University;Xinjiang Medical University Affiliated Hospital of Chinese Medicine;Xinjiang Technical Institute of Physics and Chemistry,Chinese Academy of Science;Urumqi College of Food Science and Pharmacy,Xinjiang Agricultural University;;Immunoregulation of TGF-β_1/Smads signal transduction pathway on rat lung impairment induced by PM2.5[J];西北药学杂志;2017-03
4 YU Qi;Internal Medicine Department,Daqing Hospital of Traditional Chinese Medicine;;Clinical Observation on the Treatment of IgA Nephropathy With Nephrotic Syndrome by Integrated Traditional Chinese and Western Medicine[J];中国卫生标准管理;2017-05
5 WANG Lihong;CHEN Tong;LI Wei;LU Jian;GUO Haitao;LIN Dongfang;Department of Internal Medicine,the Seventh People's Hospital of Shenyang;;Effect of mycophenolate mofetil combined hormone therapy on patients with IgA nephropathy and the influence of 24h on urinary protein and serum creatinine[J];疑难病杂志;2016-11
6 Wang Yao;Li Qiuyuan;Lv Jie;Cai Wenhui;Yan Peiyu;Wang Yaxian;Department of Microbiology and Immunology,Basic Medicine College,Heilongjiang University of Traditional Chinese Medicine;Department of Physiology,Basic Medicine College,Heilongjiang University of Traditional Chinese Medicine;Department of Nephropathy,Hei Longjiang Hospital;;The progress of the curative effect of Tripterygium Wilfordii on the systemic Lupus erythematosus[J];国际免疫学杂志;2016-06
7 WANG Wenguang;LI Hui;LIU Xiaoying;Hubei University of Chinese Medicine;Hubei Provincial Hospital of Traditional Chinese Medicine;;Experimental Study of Jinshuiqing Decoction on Model Rats of IgA Nephropathy[J];湖北中医药大学学报;2016-05
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WU Chunlin.(Department of Nephrology,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guangxi Guilin 541002,China);The relationship of immunoglobulins,complements,albumin,blood lipids with kidney pathology in patients with nephrosis[J];检验医学;2013-05
2 LI Yi-chuan,SHEN Yong-jie, LIU Guo-ling,CHANG Jing-zhi, GUO Hui (Department of Biochemistry,Shangqiu Medical College,Shangqiu 476100,Henan Province,China);Protective effect and mechanism of tripterygium wilfordii polyglycoside on the kidney in experimental diabetic rats[J];中国临床药理学杂志;2012-06
3 CHEN Xi-sheng(Department of Nephrology,Chaonan Mingsheng Hospital,Guangdong 515144,China );Clinic Efficacy of Mycophenolate Mofetil Combined with Tripterygium Glycosides for the Treatment of IgA Nephropathy[J];医学临床研究;2011-07
4 SUI Jianying Department of Nephrology,the 4th Hospital of Daqing City,Daqing 163000,China;Clnical study of Leflunomide combined with Tripterygium Wilfordii in treatment of IgA nephropathy[J];中国医药导报;2011-11
5 CHEN Xi-sheng1,ZHANG Li2(1 Department of Nephrology,Chaonan Ming Sheng Hospital,Shantou 515144,China;2 Department of Nephrology,The First Affiliated Hospital of Shantou university,Shantou 515041,China);Clinic Effect of Mycophenolate Mofetil combined Valsartan on IgA Nephropathy[J];中国医药指南;2010-20
6 HUANG Sheng,LUO Fu-zhang.Department of Nephrology,Naihai hospital affiliated to Southern Medical University,Foshan 528200,China;The treatment of Benazepril combined with Azathioprine for the IgA nephropathy[J];国际医药卫生导报;2009-20
7 MAO Ruiyang,ZHANG Yuanyuan,SUN Wenxue,et al Department of Nephrology the First Hospital Wenzhou Medical College,Wenzhou(325000);Comparison Clinical Effect of Lefunomide Combined with Medium Dose Glucocorticoid and Triptolide with Medium Dose Glucocorticoid and Routine Dose Glucocorticoid for IgA Nephropathy of Medium Albuminuria[J];中国中西医结合肾病杂志;2009-07
8 LIU Qing-yuan,XU Chang-hui,XU Shu-can.Department of Internal Medicine,The People's Hospital of Binhai County,Jiangsu,Binhai 224500,China;Observation of effects of telmisartan combined with simvastatin on diabetic nephropathy in the early stage[J];临床合理用药杂志;2009-10
9 DU Yuanyuan, LV Yinqiu, HUANGZhaoxing,et al. Department of Nephrology, the First Affiliated Hospital of Wenzhou Medical College,Wenzhou 325000, China;The predictive value of serum and urinary TGF-β_1 in development of IgA nephropathy[J];浙江医学;2008-11
10 Li Jianqiu,Zhu Caifeng,Yu Dongrong Zhejiang Chinese Medical University,Hangzhou(310053);Status and Review of Tripterygium Wilfordii Hook Preparation Treating IgA Nephrosis[J];浙江中医药大学学报;2008-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved