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《Chongqing Medicine》 2017-21
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Treatment effect of early rehabilitation training on acute cerebral infarction patients with hemiplegia and its mechanism

Dai Xianyong;Wang Yan;Chen Wei;Department of Neurology,Linhai Municipal Second People′s Hospital;  
Objective To observe the treatment effect of early rehabilitation training on acute cerebral infarction patients with hemiplegia, and to explore its possible mechanism.Methods One hundred cases of acute cerebral infarction hemiplegia in our hospital from January 2013 to June 2016 were selected and divided into the rehabilitation training group(50 cases) and control group(50 cases).The control group was given the routine medication therapy and the rehabilitation training group was given early rehabilitation training on the basis of conventional medication therapy.The functional independence assessment(FIM),Fugl-Meyer assessment(FMA) and modified Barthel index(MBI)were used to evaluate the therapeutic effect of early rehabilitation training.The level of stromal cell-derived factor-1α(SDF-1α)in peripheral blood was measured by enzyme linked immunosorbent assay, and the level of CD34~+ KDR~+ in peripheral blood was measured by flow cytometry.Results There was no statistically significant difference in the FIM total score,FIM sports function score,FMA score,MBI score,SDF-1α and CD34~+ KDR~+ levels before treatment between the rehabilitation training group and the control group(P0.05).After treatment,the FIM total score,FIM sports function score,FMA score,MBI score and SDF-1α and CD34~+ KDR~+ levels of the rehabilitation training group were higher than those of the control group,the differences were statistically significant(P0.05).Conclusion The effect of early rehabilitation training on acute cerebral infarction patients with hemiplegic is remarkable.The mechanism may be related to promoting the expression of SDF-1α and CD34~+ KDR~+ in peripheral blood.
【CateGory Index】: R743.3
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