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《Chongqing Medicine》 2017-21
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Effect of NQO1 and NQO2 expression in clinical prognosis of ovarian carcinoma

Li Li;Xiong Guoping;Gong Danni;Zhang Qinghua;Department of Gynecology and Obstetrics,the Central Hospital of Wuhan;  
Objective To investigate the effect of quinone oxidoreductase 1(NQO1) and quinone oxidoreductase 2(NQO_2)expression in the prognosis of ovarian carcinoma.Methods The two online databases were used to perform the online analysis on the NQO1 and NQO_2mRNA levels and prognosis of ovarian cancer patients,1 306 cases of ovarian cancer were performed the Kaplan-Meier analysis by using the KaplanMeier plotter(K-M plotter);578 cases of ovarian cancer in the TCGA database were performed the univariate COX regression survival analysis.Results The K-M plotter analysis showed that the NQO1 expression level had no obvious correlation with the prognosis of ovarian cancer(P0.05),the higher the NQO_2 level,the better the prognosis(HR=0.83,P=0.006 2).The COX regression survival analysis showed that the NQO1 expression level had no obvious correlation with the prognosis of ovarian cancer(P0.05),the higher the NQO_2 level,the better the prognosis(P=0.038 29).ConclusionNQO_2 expression level has no obvious correlation with the prognosis of ovarian cancer,moreover the higher the NQO_2 expression level,the better the clinical prognosis of ovarian cancer.
【CateGory Index】: R737.31
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