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《Chongqing Medicine》 2017-23
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Association of KL gene G-395A polymorphisms with coronary heart disease and serum cystatin C level in the elderly Chinese Han population in central China

Liu Wei;Zhang Shaoying;Xu Huimin;Guan Sisi;Department of Geriatrics,the Central Hospital of Wuhan city;  
Objective To investigate the single nucleotide polymorphism at G-395 Asite of the Klotho(KL)gene and to analyze its correlation with the coronary heart disease(CHD)and serum Cystatin C(Cys-C)level in the elderly Chinese Han population in central China.Methods A case-control study was conducted in 278 elderly Chinese Han population in this department,who were divided into CHD group(138cases)and control group(140cases)according to bear angiography coronary or not.G-395 Apolymorphism of KL gene was determined by TaqMan Gene probe method,and the relationship between G-395 Apolymorphism and coronary heart disease and serum Cys-C level was analyzed.Results Compared with the control group,the frequency of GG genotype of G-395 Ain CHD group was significantly higher,and the frequency of AA genotype and AG genotype was not statistically significant.The levels of Cys-C in the GG genotype were higher than those in the AA and AG genotypes both in the control group and coronary heart disease group.Conclusion In the elderly Han population in central China,the risk of suffering coronary heart disease is higher among the GG genotype of the G-395 Alocus of the KL gene.KL gene G-395 Asite gene mutation may affect the development of atherosclerosis by affecting blood Cys-C levels.
【Fund】: 湖北省武汉市科技局资助课题(201260523187-4);; 湖北省武汉市卫生和计划生育委员会科研计划资助项目(WX12C04)
【CateGory Index】: R541.4
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