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《Chongqing Medicine》 2017-26
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Study on correlation between senile hypertension complicating depression with catechol-O-methyltransferase gene polymorphism

He Yan;Yang Li;Yang Wenhui;Wei Yunhong;Wang Jun;Deng Yan;Liu Shijie;Department of Geriatrics,Affiliated Yan′an Hospital of Kunming Medical University;Department of Clinical Psychology,Yunnan Provincial Psychiatric Hospital;  
Objective To explore the correlation between catechol-O-methyltransferase(COMT)gene polymorphism and the occurrence of senile hypertension with depression.Methods Ninety-eight Han inpatients with senile hypertension complicating depression(elderly hypertension complicating depression group)in our hospitals from January 2010 to July 2014 were selected and contemporaneous 100 Han cases of senile hypertension(elderly hypertension group)and 100 healthy Han elderly people(elderly control group)served as the study subjects.PCR-RFLP was employed to detect COMT gene 1947 locus polymorphism distribution frequency for conducting analysis.Results The genotype frequencies of AA and AG at COMT 1947 locus in the elderly hypertension complicating depression group were significantly higher than those in the elderly control group(28.57%,51.02%vs.19.00%,39.00%,P0.01).The A allele frequency in the elderly hypertensive complicating depression group was significantly higher than that in the elderly control group(54.08%vs.38.50%,P0.01).The risk of hypertension complicating depression occurrence in the population carrying A allele was 1.881 times that of carrying G allele(OR=1.881,95%CI:1.261-2.807,P0.01).The various genotypes frequencies had no statistical difference between the elderly hypertension group and elderly hypertension complicating depression group(P0.05).However,the COMT 1947A/G allele frequencies had statistical difference between the two groups(P0.05).The A allele frequencies in the hypertension complicating depression group was 54.08%,which was higher than42.50%in the elderly hypertension group(P0.01),moreover the risk of depression occurrence in the population carrying A allele was 1.593 times that of carrying G allele(OR=1.593,95%CI:1.071-2.37,P0.01).Conclusion COMT gene polymorphism could have correlation with the occurrence of elderly hypertensive complicating depression.Detecting COMT 1947 locus genotype in elderly patients with hypertension can serve as an important indicator for predicting depression occurrence.
【Fund】: 云南省教育厅科学研究基金项目(2011C091);; 云南省科技厅应用基础研究-昆明医学院联合专项基金(2013FZ286)
【CateGory Index】: R544.1;R749.4
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