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《Chongqing Medicine》 2017-26
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Effects of low-dose low molecular weight heparin on lipopolysaccharide-induced acute lung injury

Liu Yu;Liu Shaozheng;Wang Xianfeng;Wang Yiqiao;Department of Anesthesiology,Wanbei Coal Electricity Group;Department of Anesthesiology,First Affiliated Hospital of Anhui Medical University;  
Objective To explore the effect of low-dose low molecular weight heparin(LMWH)on acute lung injury(ALI)induced by lipopolysaccharide(LPS).Methods Thirty-six male SD rats were divided into 3groups:normal control group(A),LPS group(B)and LPS plus LMWH group(C),12 cases in each group.ALI was induced by intraperitoneal injection of LPS 6mg/kg in group B,C.The group C accepted intraperitoneal injection of LMWH 100U/kg,the groups B accepted intraperitoneal injection of the same volume of normal saline.The animals were killed after 6h,the pathological changes of the lung were observed under light microscope.Arterial blood gases,lung wet to dry ratio(W/D)and protein content in BALF were detected;the levels of MPO and MDA in lung tissue were determined.The levels of serum interleukin1β(IL-1β),IL-6and tumor necrosis factor-α(TNF-α)were determined by ELISA method.Results The PaO2 and pH values in the group B and C were significantly lower than those in the group A,and which in the group C were markedly increased compared with those in the group B(P0.05);the lung W/D ratio,protein content in BALF,MDA and MPO levels in the lung tissue in the group B and C were significantly higher than those in the group A(P0.01),while the lung W/D ratio,protein content in BALF,MDA and MPO levels in the lung tissue in the group C were significantly decreased compared with the group B(P0.05).The levels of plasma TNF-α,IL-1βand IL-6levels in the group B and C were markedly increased compared with the group A,while which in the group C were significantly decreased compared with those in the group B(P0.01).Conclusion The LMWH treatment might attenuate LPS-induced acute lung injury.
【Fund】: 安徽省卫生厅青年基金项目(09B125)
【CateGory Index】: R459.7
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