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《Chongqing Medicine》 2017-26
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Study on correlation between levels of hs-CRP,IL-6 and MMP-9 with cerebral microbleeding

Lu Qiaoli;Li Chen;Jia Zhirong;Department of Neurology,Tianjin Fifth Central Hospital;Department of Neurology,First Hospital,Peking University;  
Objective To discuss the correlation between levels of hs-CRP,IL-6and MMP-9 with cerebral microbleeding(CMB).Methods A total of 201 of non-acute ischemic cerebrovascular were collected and performed heal MRI+susceptibilityweighted imaging(SWI).The patients were divided into the CMB group(49cases)and non-CMB group(152cases)according to the SWI examination results.The clinical data were recorded in the two groups.The levels of inflammatory mediators high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6)and matrix metalloproteinase-9(MMP-9)were tested.The Logistic regression analysis was used to analyze the relation between the levels of hs-CRP,IL-6and MMP-9with cerebral microbleeding.Results The levels of inflammatory mediators hs-CRP,IL-6and MMP-9in the CMB group were significantly higher than those in the non-CMB group(P0.05).The logisticMultivariate logistic regression analysis showed that the levels of hs-CRP,IL-6and MMP-9[ORvalue(95%CI):1.745(1.342-2.270),1.223(1.018-1.533),1.284(1.082-1.423),P0.05)]were the risk factors of CMB after adjusting the influence of age,sex and traditional risk factors.Conclusion The levels of inflammatory mediators hs-CRP,IL-6and MMP-9are closely associated with CMB,which participate in CMB occurrence.
【Fund】: 天津市卫生局科技基金(2013KZ021);; 天津市滨海区卫生局科技项目(2013BWKY025)
【CateGory Index】: R743.34
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