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《Chongqing Medicine》 2017-26
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Study on correlation between distribution of abdominal adipose tissue and insulin resistance in patients type 2 diabetes mellitus complicating obesity

Li Wei;Zhang Chenxin;Wang Ling;Cheng Xiaoguang;Deng Wei;Department of Endocrinology,Jishuitan Hospital,Fourth Clinical Medical College,Beijing University;Department of Radiology,Jishuitan Hospital,Fourth Clinical Medical College,Beijing University;  
Objective To investigate the influence of abdominal adipose tissue on insulin resistance and other metabolic indicators in the patients with type 2diabetes mellitus(T2DM)complicating obesity.Methods Fifty-one patients with newly diagnosed T2 DM complicating obesity(T2DM group)and 50 cases of simple obesity(control group)in Jishuitan Hospital were enrolled.The two groups were performed QCT for measuring the total abdominal adipose tissue volume(TAV),subcutaneous adipose tissue volume(SAV),visceral adipose tissue volume(VAV),and then the VAV/SAV ratio was calculated.Meanwhile the waist circumference,body mass index(BMI),blood uric acid(UA),total cholesterol(CHO),triglycerides(TG),high-density lipoprotein cholesterol(HDL),low density lipoprotein cholesterol(LDL),homocysteine(HCY),dosage of basal insulin(DBIns),dosage of prandial insulin(DPIns),fasting plasma glucose(FBG),fasting blood insulin(FIns)and HbA1 clevels were also measured.The relationship between TAV,SAV and VAV with HOMA-RI and other indicators was investigated.The influence of abdominal adipose tissue on insulin resistance and other metabolic indicators was determined.Results The UA,TG,LDL,FPG and HbA1 clevels in the T2 DM group were increased compared with the control group(P0.05).Compared with the control group,the SAV level in the T2 DM group was decreased(P0.05),the VAV and VAV/SAV levels were increased(P0.05).The multivariate regression analysis showed that VAV was the natural logarithm affecting In(HOMA-RI),UA,CHO,TG,LDL,HCY,DBIns(β=0.399,0.398,0.389,0.447,0.440,0.372,0.307;P0.05).TAV was the main factor affecting the waist circumference and BMI(β=0.868,0.639;P0.05).Conclusion The visceral adipose tissue volume has larger influences on insulin resistance,blood lipids,UA,HCY and DBIns.
【Fund】: 国家自然科学基金资助项目(81401407)
【CateGory Index】: R587.1;R589.2
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