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《Chongqing Medicine》 2017-26
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Observation on effect ofβ-blocker in treating dilated cardiomyopathy in children

Men Qing;Wen Enyi;Department of Pediatrics,Xinqiao Hospital of Third Military Medical University;  
Objective To observe the effect ofβ-blocker on dilated cardiomyopathy(DCM)in children.Methods Sixty-one children cases of DCM in this hospital from 1995 to 2015were retrospectively analyzed and divided into the treatment group(takingβ-blocker,n=35)and control group(non-takingβ-blocker,n=26)according to whether takingβ-blocker.The clinical effect ofβ-blocker was preliminarily observed.Results The heart rate,LVDD,LVSD and LA after treatment in the treatment group were significantly decreased compared with before treatment(P0.05),while EF was significantly increased(P0.05);LVDD after treatment in the control group was significantly decreased(P0.05),while hear rate,RV,LVDD,LVSD,LA,MV and EF had no obvious change compared with before admission(P0.05).The heart rate,LVDD,LVSD and EF after treatment had statistical difference between the treatment group and control group(P0.05),the heart function after treatment in the treatment group was significantly improved compared with the control group(P0.05).The heart function improvement degree after treatment in the patients with hypertension of the treatment group was significantly better than those with normal blood pressure(P0.05).DCM with hypertension was significantly improved after treatment and was better than DCM without hypertension(P0.05).The The heart function improvement degree after treatment in the patients with carvedilol treatment was obviously better than that in the patients with metoprolol treatment(P0.05).Conclusion β-blocker could be used in the treatment of DCM,its effect is especially good in DCM children patients with hypertension,in which the effect of carvedilol is better than that of metoprolol.
【CateGory Index】: R725.4
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