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《Chongqing Medicine》 2017-26
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Bioinformatics analysis for mmu-miR-3475-3P in cardiac development

Shen Xing;Pan Bo;Zhou Huiming;Liu Linjuan;Tian Jie;Department of Cardiology,Affiliated Children′s Hospital of Chongqing Medical University;Second Department of Pediatrics,Affiliated Hospital of Southwest Medical University;  
Objective To investigate the mmu-miR-3475-3Ppossible participating in biology process and signal pathway.Methods The expression of mmu-miR-3475-3Pin the mature mouse heart and in the embryonic mouse heart was measured by qRT-PCR.The target genes were predicted through comprehensively using the common microRNA on-line databases such as TargetScan,miRDB and miRanda,and then the obtained targeted genes were performed the gene function annotation and signal pathway analysis.Results There was significant difference between the expression of mmu-miR-3475-3Pin the embryonic mouse heart and the expression in the mature heart.Bioinformatics analysis by using TargetScan,miRDB and MiRanda on miR3475-3Prevealed that microRNA was likely to regulate 441 target genes.Conclusion mmu-miR-3475-3Pis highly expressed in the embryonic mouse heart.The target genes predicted by mmu-miR-3475-3Pare enriched in multiple signal pathways and cellular biological processes.
【Fund】: 泸州市科技厅-西南医科大学联合课题[2015lzcyds05(9/12)]
【CateGory Index】: R54
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