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《Chongqing Medicine》 2017-34
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Therapeutic effect of focused ultrasound on rabbit ear acnevv

Dong Xiaoyong;Guo zhangyou;Li Qingyi;Liu Yunchang;Tian Yu;Zhong Fangying;Zou Jianzhong;Department of Biomedical Engineering,Chongqing Medical University/State Key Laboratory of the Ministry of Education to Cultivate the Base-Chongqing Key Laboratory of Ultrasound Medical Engineering/Chongqing Key Laboratory of Biomedical Engineering/Chongqing Non-invasive Medical Collaborative Innovation Center;  
Objective To investigate the feasibility and effectiveness of focused ultrasound on the acne of rabbit ear.Methods Eighteen male rabbits were randomly divided into blank control group,model control group and ultrasound irradiation group.Acne rabbit ear model was established by Kligman's method in model control group and ultrasound irradiation group.Then,continuous ultrasonic irradiation was given in ultrasound irradiation group.Pathological changes were observed at the time of before and after ultrasound irradiation and 14 days after ultrasound irradiation.Results After modeling,hair follicle expansion,hyperkeratosis,acupoint hypertrophy were observed in blank control group.Compared with blank control group,the thickness of horn layer,the sebaceous gland diameter and other index in model control group were statistically significant(P0.01);After irradiation,there were hyperemia and edema in epidermis,angiotelectasis and inflammatory infiltrating,but coagulative necrosis in slice was not observed,14 days later,hair follicle mild expansion,mild keratosis,spiny thinning were observed in ultrasound irradiation group,when compared with model control group,the thickness of horn layer,sebaceous gland diameter and other index were decreased in ultrasound irradiation group,and the differences were statistically significant(P0.01).Conclusion The ultrasonic focusing treatment on rabbit ear acne is feasible and effective.
【Fund】: 国家重点基础研究发展计划(973计划)项目(2011CB707900);; 国家重大科学仪器设备研制专项资助项目(81127901)
【CateGory Index】: R758.733
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