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《Chongqing Medicine》 2017-34
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Study on serum S100A12 level in patients with obstructive sleep apnea hypopnea syndrome

Zhang Peng;Cheng Xiuhui;Zhang Hua;Ouyang Songyun;Li Wenlong;Guo Linqing;Xu Chao;Zu Yuna;Wu Yongxin;Department of Respiratory Medicine,Zhengzhou Central Hospital Affiliated to Zhengzhou University;Department of Respiratory Medicine,the First Affiliated Hospital of Zhengzhou University;Department of Cardiology,Zhengzhou Central Hospital Affiliated to Zhengzhou University;  
Objective To investigate the correlation and significance of S100 A12 with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods Fifty-three patients with OSAHS were chosen as OSAHS group and 46 healthy volunteers were chosen as control group.The levels of S100 A12 and hs-CRP in the two groups were compared,and its relationship with those of epworth(ESS),apnea hypopnea index(AHI),and minimum blood oxygen saturation(L-SpO2)were analysised.Results The scores of ESS,BMI,AHI,L-SpO2,hs-CRP and S100 A12 in two groups were statistically significant(P0.05).The severity of hs-CRP in severe OSAHS group was significantly higher than that of mild OSAHS group(P0.05).There was no significant difference in hs-CRP between moderate OSAHS group and mild OSAHS group and severe group(P0.05).The level of S100 A12 in severe OSAHS group was significantly higher than that of moderate OSAHS group and OSAHS mild group(P0.05).The level of S100 A12 in moderate moderate group was significantly higher than that of mild group(P0.01).hs-CRP was negatively correlated with ESS and AHI(r=0.822,0.787,P0.01),was positively correlated with L-SpO2(r=-0.740,P0.01),S100 A12 was positively correlated with ESS and AHI(r=0.707,P0.01),and negatively correlated with ESS and AHI(r=0.707,0.807,P0.01),and negatively correlated with with L-SpO2(r=-0.670,P0.01).Conclusion S100 A12 is associated with OSAHS.The higher the severity of OSAHS,the higher the S100 A12 value,which can be used as a new predictor of cardiovascular disease risk in OSAHS patients.
【Fund】: 郑州市科技攻关项目(20150055)
【CateGory Index】: R766
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