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《Chongqing Medicine》 2017-34
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Expression of HIF-2α and VEGF in colorectal cancer and its relationship with prognosis

Huang Chengcheng;Tang Chengjia;Yu Tianwu;Department of Geriatrics,the Affiliated Yongchuan Hospital of Chongqing Medical University;Department of Hepatological Surgery,the Affiliated Yongchuan Hospital of Chongqing Medical University;Department of Hepatobiliary Surgery,the Affiliated Yongchuan Hospital of Chongqing Medical University;  
Objective To study the expression of HIF-2αand VEGF in colorectal cancer and to investigate the relationship between them and clinicopathologic parameter.Methods Immunohistochemistry staining was conducted to detect the expression of HIF-2αand VEGF protein in 67 samples of colorectal tumor tissues and 67 samples of normal adjacent tissue.Results The expression of HIF-2αand VEGF in colorectal cancer tissues was significantly higher than that in adjacent tissues.The expression of HIF-2αand VEGF increased with the clinical stage and lymph node metastasis.The expression of HIF-2αincreased with the tumor volume.The expression of HIF-2αand VEGF was not related to the age,sex,tumor location and tumor differentiation of the patients.HIF-2αwas positively correlated with VEGF expression.Kaplan-Meier survival analysis showed that HIF-2αexpression was associated with survival,that is,the higher expression of HIF-2αthe worse of prognosis was obtained.Conclusion HIF-2αis involved in the process of growth,invasion and metastasis of colorectal cancer.This process may be related to the regulation of VEGF expression.
【CateGory Index】: R735.34
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