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《Chongqing Medicine》 2017-34
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Relationship between inflammatory factors and carotid atherosclerosis in OSAHS patients with type 2 diabetes mellitus

Huang Chengcheng;Tang Chengjia;Long Xiaoli;Ling Zeyi;Gao hongli;Department of Geriatrics,the Affiliated Yongchuan Hospital of Chongqing Medical University;Department of Hepatobiliary Surgery,the Affiliated Yongchuan Hospital of Chongqing Medical University;ENT-Head and Neck Surgery,the Affiliated Yongchuan Hospital of Chongqing Medical University;Department of Ultrasound,the Affiliated Yongchuan Hospital of Chongqing Medical University;  
Objective To investigate the relationship between serum inflammatory cytokines and atherosclerosis in type 2 diabetic patients with obstructive sleep apnea hypopnea syndrome(OSAHS).Methods One hundred and three patients with type 2 diabetes were divided into OSAHS group(OSAHS group)and type 2 diabetes mellitus group(non-OSAHS group)according to the results of polysomnography(PSG),and 35 healthy subjects were selected as control group.Serum levels of total cholesterol,triglyceride,fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1 c),tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP)and carotid intima-media thickness(IMT)were measured,and their relationship with OSAHS were analyzed.Results The waist circumference,BMI,FPG,HbA1 c,IMT,TNF-αand CRP in OSAHS group were significantly higher than those in non-OSAHS group(P0.05).Logistic regression analysis showed that,IMT was independently associated with TNF-αand hs-CRP.Conclusion Patients of T2 DM with OSAHS have poor blood glucose control and higher incidence of atherosclerosis.High levels of TNF-αand hs-CRP may be involved in the formation of atherosclerosis and plaque occurrence and development.
【Fund】: 重庆医科大学附属永川医院院级课题(yjlcx201541)
【CateGory Index】: R587.1;R766
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