Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Infectious Disease Information》 2017-06
Add to Favorite Get Latest Update

Study of curative effect accuracy among 3 groups of commonly used anti-HIV drugs

LUO Xiao-lu;MO Li-da;WEI Zhen-man;SU Guo-sheng;HUANG Jin-ping;WU Jing-yu;Clinical Laboratory,the Fourth People's Hospital of Nanning;  
Objective To compare clinical curative effect of 3 ART regimens in Guangxi region through a dynamic clinical trial analysis.?Methods Seventy-six HIV/AIDS patients were included in this study and randomly divided into 3 groups.AZT group was treated with AZT+3TC+EFV.The d4T group received d4T+3TC+EFV treatment.TDF group received TDF+3TC+EFV treatment.The incidence of opportunistic infections,immune reconstitution,virological response,changes of major biochemical indexes,dressing change and drug resistance were dynamically analyzed and compared in 3 groups within 30 months.Results The HIV-RNA loading was significantly decreased in 3 groups at 6 months of treatment(P0.05),while the levels of CD4+ T lymphocytes increased significantly(P0.05),but there was no significant difference among 3 groups.After 6 months of treatment,CD4+ T lymphocytes increased gradually in 3 groups.At 12 and 18 months,the increment of CD4+ T lymphocytes in d4T group was more significant than that in AZT group and TDF group(P0.05).The ALB level in 3 groups increased significantly at 6 months of treatment(P0.05),and then the change was not obvious at subsequent time points.The incidence of opportunistic infections was 15.62% in AZT group,11.53% in d4T group,27.77% in TDF group.The dressing change rate was 12.50% in AZT group,30.80% in d4T group and 16.67% in TDF group,respectively,however no significant difference was observed.Conclusions Three first-line anti-HIV drug regimens commonly used in Guangxi area have significant and similar effects,but the rate of dressing change for d4T regimen is higher due to adverse drug reactions and drug resistance,so this regimen is recommended to withdraw.
【Fund】: 南宁市兴宁区科学研究与技术开发项目(2015A15);; 十三五国家重大新药创制课题(2017ZX09009070-001-008)
【CateGory Index】: R512.91
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved