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《Infectious Disease Information》 2017-06
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Anti-demodecidosis activity and skin safety of Jatropha curcas.l leaves extract in vitro

QIAN Jiang;CHEN Jin-shan;WEN Lei;HONG Xiao-lan;TIAN Ya-lan;Department of Dermatology,175 Hospital of PLA/Affiliated Southeast Hospital of Xiamen University;  
Objective To test the application value of the extract of Jatropha curcas.l leaves in treatment of demodecidosis.Methods Jatropha curcas.l leaves were extracted with 80% ethanol by using heat reflux method.Facial sebum specimen from demodecidosis-infected patients were used to isolate and identify demodecidosis.Different concentration groups of Jatropha curcas.l leaves,2% metronidazole control group and physiological saline control group were defined.The anti-demodecidosis experiment was performed in vitro.The pH value of different concentrations of Jatropha curcas.l leaves extract was determined.Skin irritation test and acute skin toxicity test were carried out in healthy rabbits,and Jatropha curcas.l leaves and 75% ethanol served as experiment and control groups,respectively.Results The mite-killing time was(1.55±0.67) min with 50 mg/ml Jatropha curcas.l leaves extract,(1.61±0.67) min with 25 mg/ml Jatropha curcas.l leaves extract,(2.47±0.80) min with 12 mg/ml Jatropha curcas.l leaves extract,and(1.20±0.48) min with 2% metronidazole.There was no significant different between 50,25 mg/ml Jatropha curcas.l leaves extract groups and 2% metronidazole group(P 0.05).The pH value was 6.07±0.73 of 50 mg/ml Jatropha curcas.l leaves extract,6.27±0.82 of 25 mg/ml Jatropha curcas.l leaves extract and 6.35±0.83 of 12 mg/ml Jatropha curcas.l leaves extract.Score for irritation to normal and wounded rabbit skin was both 0,and acute toxicity test showed no significant toxicity.Conclusions Jatropha curcas.l leaves extract shows a remarkable activity to demodecidosis with skin safety in vitro.
【Fund】: 漳州市自然科学基金(ZZ2014J33)
【CateGory Index】: R757.3
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