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《Journal of Changsha University》 2013-05
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Advance of Human Serum Albumin Fusion Technology

ZHENG Wei;LI Jie;Yichang Humanwell Pharmaceutical Co.,Ltd;  
Human serum albumin(HSA),the most abundant protein in human blood,has an extremely long half-life time,and functions as a drug binder,making it be an ideal carrier of drugs.As a new technology of enhancing the half-life time of pharmaceuticals,HSA-based fusion technology has been rapidly developed and widely used in current drug engineering.The half-life of drugs can be extended effectively through conjugations with HSA through covalent,non-covalent binding,micro-capsuled,and protein fusion.We reviewed the methods of HSA-based fusion technology.Further investigation of interaction of HSA with its receptors could facilitate the development of this technology,and structure-based HSA fusion technology will further promote the application of HSA fusion technology in developing long-acting pharmaceuticals.
【CateGory Index】: R944
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