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《Journal of Changsha University》 2013-05
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Advance of Human Serum Albumin Fusion Technology

ZHENG Wei;LI Jie;Yichang Humanwell Pharmaceutical Co.,Ltd;  
Human serum albumin(HSA),the most abundant protein in human blood,has an extremely long half-life time,and functions as a drug binder,making it be an ideal carrier of drugs.As a new technology of enhancing the half-life time of pharmaceuticals,HSA-based fusion technology has been rapidly developed and widely used in current drug engineering.The half-life of drugs can be extended effectively through conjugations with HSA through covalent,non-covalent binding,micro-capsuled,and protein fusion.We reviewed the methods of HSA-based fusion technology.Further investigation of interaction of HSA with its receptors could facilitate the development of this technology,and structure-based HSA fusion technology will further promote the application of HSA fusion technology in developing long-acting pharmaceuticals.
【CateGory Index】: R944
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Bo1, DUAN Zuo-ying1,ZHANG Hong-mei1, LEI Jian-yong2, CHEN Yun2, TANG Yu-qing3, JIN Jian2, LI Hua-zhong1(1.Key Laboratory of Industrial Biotechnology,Ministry of Education,Wuxi 214122,China;2.School of Medicine and Pharmaceutics,Jiangnan University,Wuxi 214122,China;3.Department of Bioscience,Taishan Medical University,Taian 271000,China);Purification and Bioactivity of the Fusion Protein Human Interleukin-2/Human Serum Albumin[J];Journal of Food Science and Biotechnology;2012-03
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 Zhang Jianjun1 Gao Yuan2 Sun Wanjin2 (1.School of Pharmacy,China Pharmaceutical University,Nanjing 210009,China; 2.School of Traditional Chinese Medicine,China Pharmaceutical University,Nanjing 210009,China);Albumin as Drug Carriers[J];Progress in Chemistry;2011-08
2 GU Xiaoyu,SHANG Hanbing,ZHAO Weiguo,et al.Department of Neurosurgery,Ruijin Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200025,China;Experimental study of intraoperative fluorescence imaging for brain glioma[J];Chinese Journal of Minimally Invasive Neurosurgery;2009-10
3 WANG Li-fei,ZHU Yuan-jun,WANG Song-mei,DU Yu,YU Teng-fei,WANG Li,HONG Bin Department of Bioengineering,Institute of Medicinal Biotechnology,Chinese Academy of Medical Sciences,Beijing 100050,China;Peking University School of Pharmaceutical Science,Beijing 100191,China;Expression and purification of HIS-IFNβ fusion protein in E.coli BL21(DE3)[J];Chinese Medicinal Biotechnology;2011-01
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 CHEN Hong-mei, BAI Xue-fan, HUANG Chang-xing, HONG Sha, WANG Ping-zhong, WEI San-hua, WANG Jiu-ping (Department of Infectious Diseases, Tangdu Hospital, the Fourth Military Medical University, Xi’an 710038,Shaanxi, China);Construction and expression of eukaryotic expression vector bearing fusion gene of human IL-2 cDNA gene and Fc gene[J];Journal of Medical Postgraduates;2004-01
2 JIN Guang-ze1, DUAN Zu-ying1, ZHANG Lian-fen2, JIN Jian2, LI Hua-zhong*1(1.Key Laboratory of Industrial Biotechnology,Ministry of Education,Wuxi 214122,China;2.School of Medicine and Pharmaceutics,Jiangnan University,Wuxi 214122,China);Expression of the Fusion Protein Human Serum Album/Mutant Human Interleukin 2C125A in Pichia pastoris[J];Journal of Food Science and Biotechnology;2010-04
3 GUO Ze-feng1, DUAN Zuo-ying1,ZHANG Lian-fen1, JIN Jian1,LI Hua-zhong1,21School of Medicine;2Key Laboratory of Industrial Biotechnology, Ministry of Education,Jiangnan University, Wuxi 214122,China;Construction and expression of gene encoding interleukin-2/human serum album fusion protein in Pichia pastria[J];Journal of China Pharmaceutical University;2008-01
4 Zhou Dao-hong Shen Yuan-shan Zhao Man-rut (Department of Microbiology, Henan Medical University);The Application of MTT Colorimetric Assay to Measured the Proliferation of Lymphocytes and the Activity of Rat/Mouse IL2[J];Chinese Journal of Immunology;1986-01
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