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《Chinese Journal of CT and MRI》 2003-01
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Study of local swelling of cerebral astrocytes with CT perfusion and histopathological technique in rats

HU Ling, GAO Pei-yi.Neuroimaging Center,Tiantan Hospital,CapitalUniversity of Medical Sciences,Beijing 100050,China[  
Objective To study the effects of astrocytic swelling on localcerebral blood flow. Methods 14 male Wistar rats, weighing 250~300g wererandomly divided into control and experimental groups. T microinjection oftACPD (agonist of mGluRs) was given to the right caudatum of the rats ofthe experimental group.6 hours later, the rotation rate of the rats wascounted for 5 minutes.The water content of the brain was determined withthe dry/wet weight method.Dynamic CT perfusion images were obtainedwith computer-aided mapping. Histopathological changes of cerebral tissuewere observed with both optic and electron microscopies. Results Brainedema was induced 6 hours after tACPD injection.Swelling of the astrocyteswas observed with optic and electron microscopies.CT perfusion imagesdemonstrated a decrease of rCBF in all the 7 rats of the experimental group,a slowdown of MTT and TTP in 5 rats out of the 7 and a decrease of rCBVin 3 rats out of the 7.There was statistically significant difference of brain watercontent and rotationary rate between the rats of the control and experimentalgroups(P0.05). Conclusion Swelling of astrocytes can induce a decrease ofcerebral blood flow.[
【Fund】: 国家自然科学基金资助项目(项目编号:30070234);; 北京市自然科学基金资助项目(项目编号:7002011);; 北京市自然科学基金资助项目(项目编号:7032009)
【CateGory Index】: R816.1
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