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《Journal of Traumatic Surgery》 2018-03
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Analysis of the effectiveness and safety of tranexamic acid used in thoracolumbar fracture surgery

ZHANG Hong-zhi;WANG Xiao-yu;Department of Orthopedics,Shunyi Hospital of Beijing;  
Objective To study the effect of tranexamic acid( TXA) in the blood loss for thoracolumbar fracture surgery,and to analyze its efficacy and safety. Methods A total of 120 patients with thoracolumbar fractures were selected from Jun. 2014 to Jul. 2016 in our hospital,and divided into groups A( intravenously injecting TXA 20 mg/kg at 30 min before operation),group B( intravenously injecting TXA 10 mg/kg/h during operation),and groups C( intravenously injecting equal amount of normal saline). All patients of three groups underwent pedicle screw fixation and the differences of intraoperative blood loss,the volume of postoperative drainage,difference between preoperative and postoperative hemoglobin,blood coagulation function and the differences in risk of venous thrombosis were compared among the three groups. Results There was no significant difference in the amount of intraoperative blood loss and postoperative drainage between group A and group B( P 0. 05),but were less than group C,and the difference was statistically significant( P 0. 05). There was no statistically significant difference in prothrombin time and activated partial prothrombin time in three groups( P 0. 05). The difference of hemoglobin after operation in group C was obviously higher than group A and group B( P 0. 05),but there was no statistical difference between group A and group B( P 0. 05). There was no statistically significant difference of postoperative deep vein thrombosis incidence in three groups( P 0. 05). Conclusion Single use of TXA preoperatively or sustained use of TXA intraoperatively can obviously decrease the blood loss in thoracolumbar fracture patients after posterior approach surgery,and does not affect the function of blood coagulation,but single use of tranexamic acid preoperatively is more feasible.
【CateGory Index】: R687.3
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