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《Chinese Journal of Contemporary Pediatrics》 2019-11
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Clinical effect of the SCMC APL-2010 regimen in treatment of acute promyelocytic leukemia in children: an analysis of 44 cases

WANG Zhuo;SHEN Shu-Hong;TANG Yan-Jing;XUE Hui-Liang;HU Wen-Ting;PAN Ci;TANG Jing-Yan;GU Long-Jun;CHEN Jing;Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine;  
Objective To study the clinical effect of the SCMC APL-2010 regimen in the treatment of acute promyelocytic leukemia(APL) in children. Methods A retrospective analysis was performed for the clinical data of 44 children with APL who received treatment with the SCMC APL-2010 regimen between April 2010 and July 2016. The Kaplan-Meier survival analysis was used to evaluate event-free survival(EFS) rate and overall survival(OS) rate. Results Of the 44 children with APL, 42(95%) achieved a complete remission(CR) after one course of treatment and 1 achieved CR after two courses of treatment, with an overall CR rate of 98%. The 9-year EFS and OS rates were 96%±3% and 97.7%±2.2% respectively. As for adverse events, 41(93%) had infection, 29(66%) had granulocyte reduction, 12(27%, 1 died) had differentiation syndrome, 16(36%) had liver dysfunction, 12(27%) had adverse gastrointestinal reactions, and 7(16%) had QT prolongation, 1(2%) had orchitis, and no secondary neoplasm was observed. Conclusions Children with APL receiving the SCMC APL-2010 regimen have a good prognosis and can achieve a long-term survival, while treatment-related infection is commonly seen.[Chin J Contemp Pediatr, 2019, 21(11): 1073-1078]
【Fund】: 浦东新区科技发展基金民生科研专项资金医疗卫生项目(PKJ2016-Y36);; 国家自然科学基金(81200374)
【CateGory Index】: R733.71
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