Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Contemporary Pediatrics》 2019-11
Add to Favorite Get Latest Update

Clinical effect of the SCMC APL-2010 regimen in treatment of acute promyelocytic leukemia in children: an analysis of 44 cases

WANG Zhuo;SHEN Shu-Hong;TANG Yan-Jing;XUE Hui-Liang;HU Wen-Ting;PAN Ci;TANG Jing-Yan;GU Long-Jun;CHEN Jing;Department of Hematology/Oncology, Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine;  
Objective To study the clinical effect of the SCMC APL-2010 regimen in the treatment of acute promyelocytic leukemia(APL) in children. Methods A retrospective analysis was performed for the clinical data of 44 children with APL who received treatment with the SCMC APL-2010 regimen between April 2010 and July 2016. The Kaplan-Meier survival analysis was used to evaluate event-free survival(EFS) rate and overall survival(OS) rate. Results Of the 44 children with APL, 42(95%) achieved a complete remission(CR) after one course of treatment and 1 achieved CR after two courses of treatment, with an overall CR rate of 98%. The 9-year EFS and OS rates were 96%±3% and 97.7%±2.2% respectively. As for adverse events, 41(93%) had infection, 29(66%) had granulocyte reduction, 12(27%, 1 died) had differentiation syndrome, 16(36%) had liver dysfunction, 12(27%) had adverse gastrointestinal reactions, and 7(16%) had QT prolongation, 1(2%) had orchitis, and no secondary neoplasm was observed. Conclusions Children with APL receiving the SCMC APL-2010 regimen have a good prognosis and can achieve a long-term survival, while treatment-related infection is commonly seen.[Chin J Contemp Pediatr, 2019, 21(11): 1073-1078]
【Fund】: 浦东新区科技发展基金民生科研专项资金医疗卫生项目(PKJ2016-Y36);; 国家自然科学基金(81200374)
【CateGory Index】: R733.71
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Jing,GU Long-Jun,TANG Jing-Yan,XUE Hui-Liang,PAN Ci,YE Qi-Dong,JIANG Hua,DONG Lu,ZHOU Min,WANG Yao-Ping.Department of Hematology/Oncology,Shanghai Children's Medical Center,Shanghai Jiao Tong University School of Medcine,Shanghai 200127,China;Effectiveness of the AML-XH-99-M_3 protocol for treatment of acute promyelocytic leukemia in children[J];中国当代儿科杂志;2008-03
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Ying-Chao,FENG Lei,YIN Chu-Yun,MA Li-Na,WEI Yong-Wei,WANG Chun-Mei,SHENG Guang-Yao.Department of Pediatrics,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Effectiveness of Anti-CD47 antibody and Ara-C combination targeting therapy NOD/SCID mouse of myeloid leukemia[J];中国当代儿科杂志;2013-07
2 LIANG Xinquan,ZHU Pingan,YU Huan,et al (Department of Hematology,The Frist People's Hospital of Chenzhou,Chenzhou,Hunan 423000,China);A clinical research of using autologous bone marrow transplantation with MAC conditioning regimen in the treatment of acute promyelocytic leukemia[J];湘南学院学报(医学版);2013-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved