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《Chinese Journal of Contemporary Pediatrics》 2019-11
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A review on muscle-specific microRNAs as the biomarker for Duchenne muscular dystrophy

MENG Qi;LAN Dan;Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University;  
MicroRNA(miRNA) is a non-coding single-stranded RNA with a length of approximately 22 nucleotides and is mainly responsible for the regulation of gene expression at the post-transcriptional level. At present, miRNA have become potential biomarkers for various diseases such as tumor, leukemia, and nervous system disease. Muscle-specific microRNAs are enriched in the skeletal muscle of patients with Duchenne muscular dystrophy(DMD) and also play an important role in the pathogenesis of DMD. Creatine kinase has limited specificity in the diagnosis of DMD since its level is not significantly associated with disease severity, and therefore, it is of great clinical significance to explore whether muscle-specific microRNAs can be used as ideal biomarkers for DMD. This article reviews the research advances in this field. [Chin J Contemp Pediatr, 2019, 21(11): 1148-1152]
【Fund】: 国家自然科学基金(81760215)
【CateGory Index】: R746.2
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 XIONG Hui(Department of Pediatrics,Peking University First Hospital,Beijing 100034,China);Differential Diagnosis of Childhood HyperCKemia[J];实用儿科临床杂志;2012-08
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 NIU Jun-Wei;PU Chuan-Qiang;WANG Qian;YIN Xi;BAN Rui;CHEN Ting;MAO Yan-Ling;LIU Jie-Xiao;Department of Neurology,The Chinese PLA General Hospital;;Muscle biopsy in patients with simple elevation of serum muscle enzyme[J];国际神经病学神经外科学杂志;2015-01
2 MAO Bing;XIONG Hui1;JIAO Hui;WEI Cui-jie;DING Juan;CHANG Xing-zhi;YANG Yan-ling;WANG Shuang;WU Ye;LIU Xue-qin;CHEN Yong-hong;DU Jun-bao;LI Xue-ying;JIANG Yu-wu;QIN Jiong;Department of pediatrics,Peking University First Hospital;Department of Medical Statistics,Peking University First Hospital;;Value of muscle enzyme analysis in differential diagnosis of childhood myopathic hyper-creatine kinase-emia[J];北京大学学报(医学版);2014-01
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