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Advances in medical Treatment of Peptic Ulcer Disease

Peptic ulcer disease is a type of chronic gastric and duodenal inflammatory lesion.Infection with Helicobacter pylori is causally related to the majority of cases of both duodenal and gastric ulcer.The second most common cause of peptic ulcers is induced by administing nonsteroidal anti-inflammatory drugs.Gastric acid and pepsin as well as the host factors may also play important roles in the pathogenesis of the disease. The drugs used for treatment of peptic ulcer include antacids,inhibitors of gastric acid secretion(H2-recep- tor antagonists,muscarine receptor antagonists,proton pump inhibitors),the protective agents for mucosa, and prostaglandins.Helicobacter pylori eradication may contribute to the reduction in time needed for ulcer healing.Moreover,eradication of Helicobacter pylori infection may enhance healing of ulcers refractory to conventional therapy and substantially reduce the risk of ulcer recurrence(from 50 percent to 0 to 2 percent in 1 year).
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