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Effects of Treating Diabetes Lower Extremity Venous Disease with Lipo-prostaglandin E_1 Combined with α-lipoic Acid on Inflammatory Factors and Oxidative Stress

Jiang Ling;Wu Shu-wu;Zhou Liu-yi;Endocrinology Department of Yichun People's Hospital;  
Objective To explore the effects of treating diabetes lower extremity venous disease with lipo-prostaglandin E1 combined with α-lipoic acid on inflammatory factors and oxidative stress. Methods 82 patients with diabetes lower extremity venous disease were divided into experimental group and control group with 41 patients in each group. Patients in experimental group were treated with lipo-prostaglandin E1 combined with α-lipoic acid and those in control group were treated with lipo-prostaglandin E1. The course of treatment of two groups were three weeks. The changes of cytokines of patients in two groups before and after the treatment were observed and their curative effects were appraised. Results Hs-CRP, IL-6 and TNF-α of patients in two groups decreased significantly(P0.01) and indexes in experimental group were significantly lower than those in control group(P0.01).SOD and 8-OHd G of patients in two groups were significantly lower than those of patients before the treatment(P0.05) Indexes of experimental group were significantly lower than those of control group(P0.05) Total effective rate of experimental group was92.6%, which was significantly higher than that of control group of 75.61%(P0.05). Conclusion Treating diabetes lower extremity venous disease with lipo-prostaglandin E1 combined with α-lipoic acid is an effective drug combination regimen, which is conductive to relieving inflammatory reaction and oxidative stress state so as to improve clinical curative effects.
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