Observe the curative effect of compound preparations enalapril maleate and folic acid tablets treatment H type hypertension
Wang Yu-juan;Zhang Hong;Liu Kun;Li Quan-rui;Department of Internal medicine, Huangcun hospital of Daxing district,Beijing;Department of Infection,Xuanwu hospital of capital medical university;
Objective Explore the compound preparations enalapril maleate and folic acid tablets treatment H type hypertension and its effect on plasma homocysteine level and folate concentration. Methods 216 cases of primary hypertension patients accompanied by elevated homocysteine have been selected. These patients have been divided into observation group and control group randomly, the observation group were given 2 piece Enalapril maleate and folic acid tablet(each tablet containing 5 mg enalapril and 0.4 mg folic acid), orally 1 times a day; the control group were given 2 piece enalapril tablet(each tablet containing 5 mg enalapril), orally 1 times a day. Two groups patients were given dietary intervention, after 6months. Blood pressure, plasma homocysteine and folic acid levels were compared between the two groups before and after treatment. Results After treatment the level of homocysteine was significantly lower both the observation group and control group, the observation group was lower than the control group. Meanwhile, the folic acid level was increased significantly for both group, the observation group rise superior to control group.Furthermore, the systolic blood pressure and diastolic blood pressure decreased significantly for both group, the extent of two groups is similar. Conclusion The fixed compound preparations enalapril maleate and folic acid tablets can lower blood pressure and homocysteine level effectively,which is the ideal drug treatment H type hypertension.
【CateGory Index】： R544.1