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《Contemporary Medicine》 2017-13
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Analysis of level and influential factors of Klotho protein in secondary hyperparathyroidism resulted from chronic renal failure

Sun Chang-li;Cheng Yan;Song Dan-dan;Fan Yi-yun;Department of Nephrology, The Third Hospital of Zhengzhou;  
Objective To analyse the level and influential factors of Klotho protein in secondary hyperparathyroidism(SHPT) resulted from chronic renal failure. Methods 50 SHPT patients and 10 heslthy people were selected. The serum creatinine(Cr), blood urea nitrogen(BUN), alkaline phosphatase(ALP), calcium, phosphorus, parathyroid hormone(PTH) were detected. The serum fibroblast growth factor-23(FGF-23) and Klotho protein were measured by enzyme linked immunosorbent assay technology. Results(1) The serum Klotho was significantly lower in SHPT group than in control group(P0.05); the serum Cr, BUN, ALP, calcium,phosphorus,PTH,FGF-23 were significantly higher in SHPT group than in control group(P0.05).(2) In SHPT group, there were negative correlation between Klotho and Cr, BUN, ALP, calcium, phosphorus, PTH, FGF-23(P0.05), Multiple stepwise regression analysis showed that the influence factors of Klotho were FGF-23, Cr, BUN. Conclusion The serum Klotho in SHPT patients was significantly decreased, and FGF-23 was an important influence factor of Klotho.
【CateGory Index】: R692.5;R582.1
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【Citations】
Chinese Journal Full-text Database 3 Hits
1 LIU Qifeng;YE Jianming;LI Shasha;Department of Nephrology,Kunshan First People's Hospital Affiliated to Jiangsu University;;Klotho Alleviates Renal Interstitial Fibrosis Via Inhibition of Endoplasmic Reticulum Stress in UUO Rats[J];中国中西医结合肾病杂志;2015-03
2 ZHANG Jian-rong;SUN Zhen-xue;GENG Yan-qiu;SHAO Su-rong;Department of nephrology,General Hospital of Chinese People Armed Police Force;;The Study of secondary hyperparathyroidism of chronic renal failure hyparathroid cell resistant to fibroblast growth factor-23[J];中国急救复苏与灾害医学杂志;2013-12
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 Sun Chang-li;Cheng Yan;Song Dan-dan;Fan Yi-yun;Department of Nephrology, The Third Hospital of Zhengzhou;;Analysis of level and influential factors of Klotho protein in secondary hyperparathyroidism resulted from chronic renal failure[J];当代医学;2017-13
2 CHEN Shaoxiu;ZHANG Qiufang;HE Huaqiong;Department of Dermatology of Shiyan Taihe Hospital, the Affiliated Hospital of Hubei Medical College;Functional Laboratory of Hubei Medical College;;Tanshinone ⅡA protection mechanism of renal transplantation in rats after ischemia reperfusion injury[J];长春中医药大学学报;2017-01
3 CHEN Shaoxiu;ZHANG Qiufang;HE Huaqiong;Shiyan Taihe Hospital,Affiliated Hospital of Hubei Medical College;;Mechanism Analysis of the Effect of Bailing Capsule on Klotho Gene and Renal Function in Patients with Renal Vascular Hypertension[J];中国中医急症;2017-01
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8 SUN Jun;ZHOU Dinghua;The Second Clinical Medical College of Shanxi Medical University;Department of hepatobiliary surgery, General Hospital of rocket force;;Research progress of Klotho protein and disease[J];系统医学;2016-02
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