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《Contemporary Medicine》 2017-13
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Analysis of level and influential factors of Klotho protein in secondary hyperparathyroidism resulted from chronic renal failure

Sun Chang-li;Cheng Yan;Song Dan-dan;Fan Yi-yun;Department of Nephrology, The Third Hospital of Zhengzhou;  
Objective To analyse the level and influential factors of Klotho protein in secondary hyperparathyroidism(SHPT) resulted from chronic renal failure. Methods 50 SHPT patients and 10 heslthy people were selected. The serum creatinine(Cr), blood urea nitrogen(BUN), alkaline phosphatase(ALP), calcium, phosphorus, parathyroid hormone(PTH) were detected. The serum fibroblast growth factor-23(FGF-23) and Klotho protein were measured by enzyme linked immunosorbent assay technology. Results(1) The serum Klotho was significantly lower in SHPT group than in control group(P0.05); the serum Cr, BUN, ALP, calcium,phosphorus,PTH,FGF-23 were significantly higher in SHPT group than in control group(P0.05).(2) In SHPT group, there were negative correlation between Klotho and Cr, BUN, ALP, calcium, phosphorus, PTH, FGF-23(P0.05), Multiple stepwise regression analysis showed that the influence factors of Klotho were FGF-23, Cr, BUN. Conclusion The serum Klotho in SHPT patients was significantly decreased, and FGF-23 was an important influence factor of Klotho.
【CateGory Index】: R692.5;R582.1
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