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《Contemporary Medicine》 2017-35
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Effect of low-dose methylprednisolone on tumor necrosis factor α in infants with mycoplasma pneumoniae pneumonia

Wei Rui-hong;Department of Pediatrics, Juye County Hospital of Traditional Chinese medicine;  
Objective To observe the clinical application of small dose of methyl prednisolone for mycoplasma pneumoniae pneumonia in infants and young children the influence of tumor necrosis factor alpha levels. Methods Selected 72 cases of pneumonia mycoplasma pneumonia in children, according to random number table method were randomly divided into conventional treatment group and the intervention treatment group of 36 cases, conventional treatment group routine clinical treatment pre-operation, intervention in the treatment group on the basis of routine treatment group with treatment give a prednisolone intravenous drip, and randomly selected from the same period in our hospital medical outpatient medical examination of 36 cases of healthy infants and young children as control group, comparison and analysis of three groups of children serum tumor necrosis factor alpha levels. Results The total effective treatment in children with intervention therapy group was obviously higher than that of conventional treatment group(P0.05), before regular treatment group and intervention group of children with treatment of serum TNF alpha levels were significantly higher than that of control group(P0.05), 4 d, 7 d after treatment intervention group of TNF alpha level significantly decreased in the conventional treatment group(P0.05), 7 d after treatment TNF alpha level intervention in the treatment group and control group was no significant difference, and level of TNF alpha is still routine therapy group was obviously higher than that of control group(P0.05). Conclusion Small doses of a prednisolone can obviously reduce the mycoplasma pneumoniae pneumonia in infants and young children the tumor necrosis factor alpha levels, ease the body's inflammatory response, improve the clinical curative effect, is worth popularizing application.
【CateGory Index】: R725.6
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