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《Contemporary Medicine》 2018-24
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Effect of herpes puncture drainage combined with interferon on the level of T lymphocyte subsets and inflammatory factors in children with hand foot and mouth disease

Xu Dingjuan;Department of infectious diseases,Tengnan hospital,Zaozhuang mining group;  
Objective To investigate the effect of herpes puncture drainage combined with interferon on the level of T lymphocyte subsets and inflammatory factors in children with hand foot and mouth disease.Methods 118 cases of hand foot and mouth disease in our hospital during the period of December 2016 to December 2017 were selected as the research object.The control group and the observation group were randomly divided into 59 cases.All children received routine symptomatic treatment after admission,while the control group was given ribavirin treatment.The observation group was given herpes puncture drainage combined with interferon on the basis of the control group.The changes of T lymphocyte subsets and inflammatory factors before and after treatment in the two groups were compared and the clinical effects were compared.Results The two groups before treatment the level of inflammatory cytokines and T lymphocyte subsets were no significant difference;CD3+,CD4+,CD4+/CD8+after treatment,CD8+levels were elevated,TNF-alpha,IL-6 and IL-10 decreased(P0.05);the observation group after treatment CD3+,CD4+and CD4+/CD8+levels were higher than the control group,CD8+,TNF-alpha,IL-6 and IL-10 were lower than the control group(P0.05);the total efficiency of the observation group was significantly higher than the control group(P0.05).Conclusion Herpes puncture and drainage combined with interferon enhanced the immune function of children with hand foot mouth disease,and inhibited the inflammatory reaction.The clinical efficacy was significant,and it is worthy of popularization and application.
【CateGory Index】: R725.1
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