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《Contemporary Medicine》 2018-24
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Research Progress in Myasthenia Gravis Related Autoantibodies

Deng Shujing;Tan Yeqing;Beijing North Institute of Biological technology;  
Myasthenia gravis(MG) is a multi-factor controlled autoimmune disease in which the autoantibodies in the patient's serum attack the ion channel proteins and other proteins at the neuromuscular junctions,result in affecting neurotransmitter transmission.Clinical symptoms mainly include fatigue,muscle weakness and so on.Detection of ACh R-Ab and Mu SK-Ab can provide an important basis for the diagnosis of MG disease.In addition,recent studies have found that there are other autoimmune antibodies in MG patients,such as lipoprotein receptor-associated protein 4 antibody,ryanodine receptor antibody,and serum Titin antibody.Presynaptic membrane(Prsm) antibody.Although the mechanism of action of these autoimmune antibodies in the pathogenesis of the disease is not clear,and the correlation between ACh R-Ab,Mu SK-Ab,and other MG-associated muscle autoantibody levels in serum of patients with MG and disease severity has not been proved.,it provides an important basis for the identification of subtypes of MG.This article reviews the research progress of myasthenia gravis-related autoimmune antibodies.
【CateGory Index】: R746.1
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