Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 1984-03
Add to Favorite Get Latest Update

A STUDY ON THE SYNTHESIS OF PYRITHIONE SODIUM

Xu Bingxing, et alDepatment of reseach of Traditional Chinese and western medicine, Faculty of pharmacy  
Polyanemine (zinc salt of 2-mercaptopyrine-N-oxide)exhibited not only the activity against plasmodium berghei in the mice but also the activity against microorganisms in vitro. In order to reaeach a new drug possessing the high activity and little toxi-city,a series of analogs of polyanemine was synthesized and tested for its antimicrobial effect, and one of these, pyrithione sodium (Sodium salt of 2-mercaptopyridine-Na oxide)was found to be the most active compound against the wide range of microorganisms by test in vitro and clinical application. In vitro the minimal Inhibiting concentration (MIC) rangs from 0.25μg/ml to 80μg/ml for 17 strains of common fungal pathogens and from 0.63μg/ml to 16μg/ml for 12 strains of common bacterial pathogens. It was synthesiyed by an six-step precedure starting with 2-aminopyridins procured from the local market. The total yield was 37.6%. The mp IR UV spectra of the product were in accord with report mentioned in the foreign literature.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 1 Hits
1 Li Xiukai, et al(Department of Dermatology, Changhai Hospital);EXPERIMENTAL STUDY OF INHIBITING CANDIDA ALBICANS WITH SODIUM PYRITHIONE[J];Academic Journal of Second Military Medical University;1988-01
【Co-citations】
Chinese Journal Full-text Database 1 Hits
1 Tan Jianquan, Zheng Linzhong, Qiu ChengzhiDepartment of Pharmacology;ACUTE INTOXICATION OF PYRITHIONE IN NON-ANESTHETIZED DOGS[J];Academic Journal of Second Military Medical University;1984-03
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Xu Bingxiang, et alDepartment of Research of Traditional Chinese and Western Medicine,Faculty of Pharmacy;A STUDY ON THE ACTIVE PRINCIPLE OF POLYALTHIA NEMORALIS II. THE SYNTHESIS OF NATURAL OCCURRING METALLIC COMPOUND ZINCPOLYANEMINE[J];Academic Journal of Second Military Medical University;1982-03
2 Tan Jianquan, Zheng Linzhong, Qiu ChengzhiDepartment of Pharmacology;ACUTE INTOXICATION OF PYRITHIONE IN NON-ANESTHETIZED DOGS[J];Academic Journal of Second Military Medical University;1984-03
3 Zhang Zhenming (Division of Chemistry Lianyungang Chinses Herb Medicine School Lianyungang, 222005);Synthesis of 2 - Mercaptopyridine - N - Oxide Sodium Salt[J];Chemical Industry Times;1999-12
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 LU Lian-ying,QU Zhang-yu(Department of Chemistry and Environment,Hubei Normal University,Hubei Huangshi 435002,China);Thermal Decomposition Kinetics of Complexes of 2-Mercaptopyridine with Cd(Ⅱ),Hg(Ⅱ)[J];Chemical World;2008-03
2 LU Lian-ying,WANG Dun-jia,WEI Xian-hong,LI Min(Dept., of Chemistry and Environment, Hubei Normal Univ., Huangshi 435002, China);SYNTHESIS AND CHARACTERIZATION OF CHELATES OF 2-MERCAPTOPYRIDINE WITH CO(Ⅱ)-MN(Ⅱ)[J];Journal of Jiamusi University(Natural Science Edition);2005-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved