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《Academic Journal of Second Military Medical University》 2012-01
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Sex-dependent differences in DNA copy number alterations in hepatocellular carcinoma

WEN Bing-ji1,CONG Wen-ming2,WANG Ai-zhong3,HE Song-qin1,JIANG Hong-mei4,DONG Hui2,HOU Li-fang5,ZHU Zhong-zheng1 1.Department of Oncology,No.113 Hospital of PLA,Ningbo 315040,Zhejiang,China 2.Department of Pathology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China 3.Department of Pathology,No.113 Hospital of PLA,Ningbo 315040,Zhejiang,China 4.Department of Statistics,Northwestern University,Evanston,IL 60208,USA 5.Robert H.Lurie Comprehensive Cancer Center,Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,USA  
Objective To identify the sex-related DNA copy number alterations(CNA) in hepatocellular carcinoma(HCC).Methods High-resolution array comparative genomic hybridization(array-CGH) was used to examine 17 female and 46 male HCCs.Two-tailed Fisher's exact test or χ2 test was used to compare the differences in CNA between females and males.Results The overall frequencies and patterns of CNA in female and male cases were similar.However,female HCC tumors presented more copy number gains compared to male on 1q21.3-q22(76.5% vs 37.0%,P=0.009),11q11(35.3% vs 0.0%,P=0.000 2) and 19q13.31-q13.32(23.5% vs 0.0%,P=0.004),and more loss on 16p11.2(35.3% vs 6.5%,P=0.009).Relative to females,male cases had more copy number loss on 11q11(63.0% vs 17.6%,P=0.002).Further analyses showed that 11q11 gain was correlated with 19q13.31-q13.32 gain(P=0.042) and 16p11.2 loss(P=0.033),while 1q21.3-q22 gain was correlated with 19q13.31-q13.32 gain(P=0.046).Conclusion Our findings suggest that CNA may play an important role in sex-related difference in HCC development.
【Fund】: 国家自然科学基金(30470791);; 南京军区医学科技创新基金(08MA023 09MA043);; 宁波市自然科学基金(2009A610126)~~
【CateGory Index】: R735.7
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【References】
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1 LI Ye-ping;XIONG Qian;LI Jin-ju;LI Guo -huan;Department of Liver Disease,Zhuhai Hospital,Guangdong Provicinal Hospital of Chinese Medicine;;A retrospective analysis of the gender distribution in ten years' hospitalized patients with liver cirrhosis and hepatocellular carcinoma of hepatitis B in our hospital[J];甘肃医药;2014-06
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1 HOU Jia-jie,JIANG Run-qiu,DENG Lei,CHEN Chen,SUN Bei-cheng(Institute of Liver Transplantation,Key Laboratory of Liver Transplantation of Health Ministry,the First Affiliated Hospital of NJMU,Nanjing 210029,China);Study of PTPRO level in human hepatocellular carcinoma and its correlation with gender and prognosis[J];南京医科大学学报(自然科学版);2012-06
2 WEN Bing-ji1,CONG Wen-ming2,WANG Ai-zhong3,HE Song-qin1,JIANG Hong-mei4,DONG Hui2,HOU Li-fang5,ZHU Zhong-zheng1 1.Department of Oncology,No.113 Hospital of PLA,Ningbo 315040,Zhejiang,China 2.Department of Pathology,Eastern Hepatobiliary Surgery Hospital,Second Military Medical University,Shanghai 200438,China 3.Department of Pathology,No.113 Hospital of PLA,Ningbo 315040,Zhejiang,China 4.Department of Statistics,Northwestern University,Evanston,IL 60208,USA 5.Robert H.Lurie Comprehensive Cancer Center,Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,USA;Sex-dependent differences in DNA copy number alterations in hepatocellular carcinoma[J];第二军医大学学报;2012-01
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1 WANG Xiao-qiong;ZHANG Guo-qing;LIU Zhong-qin;WANG Ying;LIU Zhao-hong;CUI Jia;Shouguang Municipal Center for Disease Control and Prevention;;Epidemiological trend of hepatitis B, hepatitis B related liver cirrhosis and liver cancer in Shouguang, Shandong Provinc[J];疾病预防控制通报;2015-04
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