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《Academic Journal of Second Military Medical University》 2012-01
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Expression of CXCR4 in gastric cancer and its relationship with patient prognosis

ZHU Zhi-qiang,NING Zhong-liang,SHAO Feng,HU Bin,LIANG Wei Department of General Surgery,The Affiliated Provincial Hospital of Anhui Medical University,Hefei 230001,Anhui,China  
Objective To discuss the relationship of CXCR4 expression with clinical pathology,post-operative metastasis,recurrence and prognosis of gastric cancer patients.Methods A total of 141 gastric cancer tissues and the corresponding adjacent tissues were taken from patients who were treated in the Department of General Surgery,The Affiliated Provincial Hospital of Anhui Medical University between November 2007 to November 2008.Immunohistochemistry was performed to detect the CXCR4 expression in the gastric cancer tissues and adjacent tissues;the relationship of CXCR4 expression with clinical pathology of the patients was analyzed.The relationship of CXCR4 expression with recurrence and prognosis was analyzed based on a 3 year-follow-up.Results The positive rate of CXCR4 was 60.3%(85/141) in gastric cancer tissues,which was significantly higher than that in the corresponding adjacent tissues 26.2%(37/141,P0.05).CXCR4 expression in the gastric cancer tissues was positively correlated with the TNM stage,depth of invasion,invasion of the pancreas capsule,and lymphatic metastasis(P0.05).Logistic multivariate regression analysis showed that lymphatic metastasis and recurrence after surgery were correlated with the expression of CXCR4 in gastric cancer tissues(P0.05).The 3-year survival rate of patients with CXCR4 expression was significantly lower than patients without CXCR4 expression(43.1% vs 56.6%,P0.05).Conclusion CXCR4 is over-expressed in gastric cancer tissues,and the expression is positively correlated with the lymphatic metastasis and recurrence after surgery.CXCR4 positive patients have a lower survival rate than patients without CXCR4 expression;all these makes CXCR4 a possible molecular marker for lymphatic metastasis,postoperative recurrence and prognosis in gastric cancer.
【CateGory Index】: R735.2
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【Co-citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Dan-jie,CHE Xiang-ming,LIU Rui-ting Department of General Surgery,The First Affiliated Hospital of Xi'an Jiaotong University,Xi'an 710061,China.;Relation between lymph node metastasis and prognosis in patients with gastric cancer[J];Journal of Modern Oncology;2010-02
2 YU Jun-xiu, WU Yu-lian, YANG Li-tao.Department of Surgery, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China;The value of metastatic lymph nodes ratio in predicting the prognosis of patients with T_3 gastric carcinoma[J];National Medical Journal of China;2005-13
3 ZHANG Dan-jie,CHE Xiang-ming,LI Hai-jun,LIAO Xin-hua,GAN Jian-xin.Department of General Surgery,The First Affiliated Hospital of Medical College of Xi'an Jiaotong University,Xi'an 710061,Shaanxi Province,China;Relation Between Histology Type and Prognosis of Gastric Cancer[J];Chinese Journal of Bases and Clinics in General Surgery;2011-05
4 Yong-Bin Ding Guo-Yu Chen Jian-Guo Xia Xi-Wei Zang Hong-Yu Yang Li Yang Department of General Surgery,First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,Jiangsu Province,China Yue-Xian Liu Nanjing University of Traditional Chinese Medicine,Nanjing 210029,Jiangsu Province,China;Correlation of tumor-positive ratio and number of perigastric lymph nodes with prognosis of patients with surgically-removed gastric carcinoma[J];世界胃肠病学杂志(英文版);2004-02
5 Chang-Ming Huang, Bi-Juan Lin, Hui-Shan Lu, Xiang- Fu Zhang, Ping Li, Jian-Wei Xie, Department of Oncology, Affiliated Union Hospital of Fujian Medical University, Fuzhou 350001, Fujian Province, China;Prognostic impact of metastatic lymph node ratio in advanced gastric cancer from cardia and fundus[J];世界胃肠病学杂志(英文版);2008-27
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