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《Academic Journal of Second Military Medical University》 2012-01
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CAS protein expression in invasive breast ductal carcinoma and its relationship with cell proliferation and apoptosis

XU Jun1,HU Yong1,WANG Jian1,WANG Xing-xing1,ZHANG Tai-ping1,YU Hong-yu2 1.Department of Pathology,No.105 Hospital of PLA,Hefei 230031,Anhui,China 2.Department of Pathology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China  
Objective To analyze the relationship of CAS protein expression with proliferative index,apoptosis index and clinical parameters in breast cancer tissues.Methods Immunohistochemistry for CAS expression,ki-67(proliferative index) and TUNEL(apoptosis index) were examined in 20 usual ductal hyperplasia(UDH),20 atypical ductal hyperplasia(ADH),10 ductal carcinoma in situ(DCIS),53 invasive ductal carcinoma(IDC) and 14 normal breast tissues.Results CAS expression increased in order in the normal breast tissues,UDH,ADH,DCIS and IDC,with the positive rates of CAS protein being 14.3%(2/14),25.0%(0/20),40.0%(8/20),60.0%(6/10),and 75.5%(40/53),respectively(χ2=29.382,P=0.000).CAS protein expression was correlated with histological grade,mitotic activity,and lymph node metastasis of IDC(P0.01,P0.05),and not with patient age,tumor volume or grade.CAS protein expression was positively correlated with ki-67 index(r=0.439,P=0.003),and not with the apoptosis index(r=0.248,P=0.083).Conclusion CAS protein expression is associated with cell proliferation index in breast cancer tissues.
【CateGory Index】: R737.9
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