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《Academic Journal of Second Military Medical University》 2012-01
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Pharmacokinetics and relative bioavailability study of multiple oral doses of pyridostigmine bromide sustained-release tablets in rabbits

XIONG Hua-rong1,TAN Qun-you2,LIAO Hong1,TENG Yong-zhen1,WANG Rui1,ZHANG Jing-qing1 1.Medicine Engineering Research Center,Chongqing Key Laboratory of Biochemical and Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,China 2.Department of Thoracic Surgery,Institute of Surgery Research,Daping Hospital,Third Military Medical University,Chongqing 400042,China  
Objective To evaluate the pharmacokinetics and the relative bioavailability of pyridostigmine bromide sustained-release tablets(PBSTs) by comparing with the conventional tablets using a multiple-dose design. Methods Six rabbits were randomly divided into 2 groups and were assigned to a self crossover design.The plasma pyridostigmine bromide concentration was determined by high-performance liquid chromatography as multiple oral dose of PBSTs(90 mg each time,and twice a day) or conventional tablets(60 mg each time,three times a day).The pharmacokinetic parameters and relative bioavailability were calculated.Results A two-compartment model was used to describe the in vivo behavior of PBSTs after oral administration.The main pharmacokinetic parameters for conventional tablets and multiple oral dose of PBSTs were calculated as the follows: tmax(2.00±0) and(4.00±0) h;Cmax(25.48±0.18) mg/L and(19.24±0.45) mg/L;AUC0-∞(321.42±5.00) mg·h·L-1 and(370.08±12.23) mg·h·L-1.The relative bioavailability of the sustained-release tablets was 119.15% compared with the conventional tablets. Conclusion PBSTs has the property of sustained-relsease and is bioequivalent to the conventional tablets.
【Fund】: 教育部博士点基金(20095503120008);; 重庆市教育委员会资助项目(首批高等学校优秀人才资助 KJ 090308)~~
【CateGory Index】: R96
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【Citations】
Chinese Journal Full-text Database 2 Hits
1 FU Wen-huan,SHI Xiao-jin,LI Zhong-dong,ZHONG Ming-kang,XU Lu-yang(Department of Clinical Pharmacology,Huashan Hospital Affiliated to Fudan University,Shanghai 200040,China);Determination of Pyridostigmine Bromide in Human Plasma by RP-HPLC[J];Chinese Pharmaceutical Journal;2007-12
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 CHAI Yi-feng*,ZHU Zhen-yu and CHEN Xiao-fei(Department of Pharmaceutical Analysis,School of Pharmacy,Second Military Medical University,Shanghai 200433),Fenxi Shiyanshi,2010,29(9):78~122;Pharmaceutical analysis(I)[J];Chinese Journal of Analysis Laboratory;2010-09
2 WANG Hong1,TAN Qun-you2,ZHANG Li1,CHENG Xun-guan3,ZHANG Jing-qing1 1Medicine Engineering Research Center in University,3Research Lab of Medicinal Chemistry and Biological Material,Chongqing Key Laboratory of Biochemical&Molecular Pharmacology,Chongqing Medical University,Chongqing 400016,China;2Department of Thoracic Surgery,Daping Hospital & Research Institute of Surgery,Third Military Medical University,Chongqing 400042,China;Bioequivalence of pyridostigmine bromide dispersible tablets in rabbits[J];Journal of Southern Medical University;2011-10
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