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《Academic Journal of Second Military Medical University》 2012-02
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Correlation analysis of gene polymorphisms of TNF-α and its receptors with rheumatoid arthritis susceptibility and related serological markers

GUO Xin-ling1,YOU Chong-ge1,WANG Li-ping2,MA Ke-jun1,ZHOU Ya-li1,SHI Xin-he1,LI Fei-fei1,GAO Li-na3 1.Central Laboratory,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China 2.Department of Rheumatism,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China 3.Clinical Laboratory Center,Lanzhou University Second Hospital,Lanzhou 730030,Gansu,China  
Objective To investigate the correlation of gene polymorphisms of TNF-α and its receptor with rheumatoid arthritis(RA) susceptibility and the related serological markers in the Han nationality living in northwest China.Methods The gene polymorphisms of TNF-α and its receptor(TNFA-857CT,TNFA-863CA,TNFA-308GA,TNFA-238GA,TNFR1-383AC,TNFR2-exonTG) were determined by high resolution melting(HRM) in 452 RA patients and 356 controls in a case-control manner.Anti-cyclic citrullinated protein antibodies(anti-CCP) and rheumatoid factors(RF) were measured by clinical conventional methods,and their association with the gene polymorphisms of TNF-α and its receptor was analyzed.Results Significant differences were found in the distribution frequencies of TNFA-308GA and-863CA between RA cases and healthy controls(P=0.001,P=0.002),but not in the frequencies of TNFA-238GA,TNFA-238AA,TNFR2-exonTG or TNFR2-exonGG(P=0.701,P=0.999,P=0.825,P=0.330).In addition,significant differences were also found in the distribution frequencies of TNFA haplotypes of-238G/-308A/-863C(GAC),-238G/-308G/-863A(GGA) and-238G/-308G/-863C(GGC) between the two groups(P=0.016,P=0.033,P=0.023).Furthermore,we found that RA serological markers(RF,anti-CCP) were not significantly correlated with the gene polymorphisms of TNF-α and its receptors.Conclusion TNFA-308GA and TNFA-863CA are associated with RA susceptibility in Han nationality living in northwest China,so are the TNFA haplotypes of GAC,GGA and GGC.Gene polymorphisms TNF-α and its receptor have no significant correlation with RA serological markers.
【Fund】: 甘肃省科技支撑计划(090NKC094)~~
【CateGory Index】: R593.22
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