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《Academic Journal of Second Military Medical University》 2012-02
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Recombinant tissue factor-based thromboplastin reagents: research progress

SUN Jin-xia1,GUO Zhen-zhong3,SUN Lei1,JING Yuan-xia1,HUANG Yao-jiang1,2 1.College of Life and Environment Science,Minzu University of China,Beijing 100081,China 2.Chinese Institute of Environment and Resource Protection for Minority Areas,Beijing 100081,China 3.General Hospital of Fengfeng Group,Jizhong Energy Group,Handan 056200,Hebei,China  
Thromboplastin reagents were made from natural tissues of human or animals before the emergence of tissue factor(TF) which can be purified in 1990s.In recent years,highly purified recombinant tissue factor(rTF) or soluble tissue factor(sTF) has been used to prepare thromboplastin reagents.This article reviewed the evolution of technique for preparing recombinant tissue factor-based thromboplastin reagents both at home and abroad,and summarized the advantages of recombinant tissue factor and analyzed the future of thromboplastin reagents.It has been pointed out that highly sensitive and stable thromboplastin reagents are needed in the future.
【Fund】: 高等学校学科创新引智计划(B08044);; 国家“985”及“211”工程项目(CUN985-3-3);; 北京市校企合作产学研项目~~
【CateGory Index】: R446.11
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【Citations】
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