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《Academic Journal of Second Military Medical University》 2012-02
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Changes of monocyte chemoattractant protein-1 content in adenomyotic tissue and its significance

LI Juan1,2,WEN Ze-qing1,YIN Ge-ping2,CHEN Ming2,CHEN Ying-jian2 1.Department of Gynecology and Obstetrics,Provincial Hospital of Shandong,Shandong University School of Medicine,Ji'nan 250020,Shandong,China 2.Department of Gynecology and Obstetrics,General Hospital of Ji'nan Military Area Command,Ji'nan 250031,Shandong,China  
Objective To investigate the role of monocyte chemoattractant protein-1(MCP-1) in the pathogenesis of adenomyosis.Methods MCP-1 was examined by immunohistochemistry method and real-time PCR in the eutopic endometrium and ectopic endometrium of 36 patients with adenomyosis,and the results were compared with those of controls.Results MCP-1 contents in the eutopic endometrium and ectopic endometrium of patients with adenomyosis were significantly higher than those of normal controls(P0.05).The contents in ectopic endometrium tissue was significantly higher than that in eutopic endometrium tissue(P0.05),and the contents in the two tissues were significantly correlated with each other(r=0.87,P0.01). Conclusion MCP-1 may be involved in the pathogenesis of adenomyosis,but the specific molecular mechanisms need further study.
【CateGory Index】: R711.71
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