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《Academic Journal of Second Military Medical University》 2012-12
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Cyclic dipeptides in actinomycete Brevibacterium sp. associated with sea cucumber Apostichopus japonicus Selenka: isolation and identification

GONG Jun1,TANG Hua1,GENG Wan-li1,LIU Bao-shu1,SUN Peng1,LI Ling1,LI Zhi-yong2*,ZHANG Wen1* 1.Research Center for Marine Drugs,School of Pharmacy,Second Military Medical University,Shanghai 200433,China 2.Marine Biotechnology Laboratory,School of Life Sciences and Biotechnology,Shanghai Jiaotong University,Shanghai 200240,China  
Objective To investigate the secondary metabolites of actinomycete Brevibacterium sp. associated with the sea cucumber Apostichopus japonicus Selenka.Methods The ethyl acetate extract of the actinomycete was purified by repeated column chromatography on silica gel,Sephadex LH-20,and high-performance liquid chromatography(HPLC) to obtain pure compounds;and the compound structures were elucidated by spectroscopic analysis(nuclear magnetic resonance,NMR;mass spectrometry,MS) and the results were compared with the previously reported data.Results Seven compounds were isolated: cyclo-(L-Pro-L-Phe)(1),cyclo-(L-Pro-L-Met)(2),cyclo-(L-Pro-L-Tyr)(3),cyclo-(L-Pro-L-Val)(4),cyclo-(L-Pro-L-Pro)(5),cyclo-(L-Val-Gly)(6),and cyclo-(L-Pro-L-Leu)(7).Conclusion This is the first report on the secondary metabolites of microorganisms associated with the sea cucumber Apostichopus japonicus Selenka,and all the seven compounds have been reported from the actinomycete Brevibacterium sp. for the first time.
【Fund】: 国家自然科学基金(30873200 41176125);; 上海市浦江人才计划(PJ2008)~~
【CateGory Index】: R915
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