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《Academic Journal of Second Military Medical University》 2017-12
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Research progress on role of macrophage in fracture healing

ZHOU Xiao-yi;WU Sui-yi;ZHANG Zi-cheng;WANG Fei;YANG Yi-lin;XU Xi-ming;LI Ming;WEI Xian-zhao;Department of Spine Surgery,Changhai Hospital,Second Military Medical University;The Third Student Team,Student Brigade,Second Military Medical University;Department of Spine Surgery,Changzheng Hospital,Second Military Medical University;  
Inflammatory reaction plays an important role in hematoma formation,tissue debris removal and fibrous tissue formation during the first stage of fracture healing.M1 and M2 macrophages participate in the process of fracture healing through pro-inflammatory and anti-inflammatory effects,respectively.Tumor necrosis factor α,interleukin and other cytokines secreted by macrophages can regulate the activities of osteoblasts and osteoclasts.Bone tissue bioengineering studies found that functional tissue engineering can promote angiogenesis and fracture healing by regulating inflammatory reaction.Therefore,exploring the role of macrophages in the process of fracture healing may provide new insights for promoting fracture healing.
【Fund】: 国家自然科学基金(81301554);; 上海市自然科学基金(13ZR1450200);; 上海市卫生与计划生育委员会科研课题(20154Y0018)~~
【CateGory Index】: R683
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