Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Academic Journal of Second Military Medical University》 2017-12
Add to Favorite Get Latest Update

Clinical correlation analysis of placenta growth factor expression in human seminal plasma and oligoasthenospermia

YAN Tao-fei;ZHANG Wen-hui;YE Yu-sheng;XU Ya-jun;HONG Yi;ZHU Ya-qing;WANG Yue;YAN Hong-li;ZHANG Hui-qin;SUN Fang-zhen;Department of Reproductive Medicine Center,Changhai Hospital,Second Military Medical University;Department of Histology and Embryology,College of Basic Medical Sciences,Second Military Medical University;  
Objective To explore the correlation between placental growth factor(PlGF)expression and sperm quality in seminal plasma,and to evaluate its clinical significance in patients with oligoasthenospermia and azoospermia.Methods A total of 88 patients undergoing seminal fluid detection were enrolled from the Department of Reproductive Medicine Center of Changhai Hospital of Second Military Medical University from Sep.2014 to Nov.2014.The patients were divided into three groups according to the test results:ten cases with normal semen(normal group),68 cases with oligoasthenospermia(oligoasthenospermia group),and ten cases with azoospermia(azoospermia group).Semen samples from five patients with normal semen and 5 patients with oligoasthenospermia were collected and assayed for cytokinerelated protein microarray.The contents of PlGF in seminal plasma were detected by ELISA.The correlations between PlGF concentration and the sperm concentration and activity in seminal plasma and the age of patients were analyzed by Pearson correlation analysis.Results The contents of PlGF in seminal plasma in the normal group were significantly higher than that in the oligoasthenospermia and azoospermia groups(P0.05).The level of PlGF in seminal plasma was related to the concentration and activity of sperm(r=0.362,0.253;P0.05),but not to the age of patients.Conclusion The level of PlGF in seminal plasma is correlated with the sperm concentration,providing reference for diagnosis and treatment of oligoasthenospermia and azoospermia in clinic.
【CateGory Index】: R698.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved