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《Academic Journal of Second Military Medical University》 2017-12
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Mesoporous silica nanocapsules loaded liposomes negatively enhance magnetic resonance T_2 weighted imaging

LI Ye-kuo;TANG Jia-wei;DUAN Wan-lu;HE Jing-ling;YAN Fei;ZHENG Hai-rong;Department of Ultrasound,Guangzhou General Hospital of PLA;Shenzhen Institutes of Advanced Technology,Chinese Academy of Sciences;  
Objective To detect the relaxation property of mesoporous silica nanocapsules loaded liposomes(MSN-LIPO),and to explore their functions of enhancing MRI T_2 weighted imaging.Methods In vitro,MSN-LIPO with different iron concentrations were scanned by MRI system to detect their relaxation properties.In vivo,six BALB/c nude mouse models with subcutaneous malignant glioma were established and randomly divided into two groups,which were injected with the same concentration of MSN-LIPO intratumorally and intravenously,respectively.The mice in the two groups were scanned by MRI before and after injection,and the image characteristics were studied and the signal intensity of tumors was statistically analyzed.Results In vitro MRI imaging showed that the signal intensities of the images were gradually decreased with the increase of iron concentrations in MSN-LIPO,and 1/T_2 had a good linear relationship with the concentration within a certain range,with the relaxation rate(r2)being 413.7 mmol~(-1)·s~(-1).MRI imaging of BALB/c nude mouse models with malignant glioma showed that the signal intensity of the tumor after intratumor injection of MSN-LIPO was significantly lower than that before intra-tumor injection(15.34±1.24 vs 211.44±5.34,t=36.38,P 0.05),and the signal intensity of the tumor after intravenous injection of MSN-LIPO was significantly lower than that before intravenous injection(179.00±4.35 vs 235.99±5.17,t=14.34,P0.05).Conclusion MSN-LIPO has good magnetic relaxation property and good MRI T_2 weighted contrast enhancement function in vivo,suggesting that it can be used as a MRI T_2 contrast agent.
【Fund】: 广东省自然科学基金项目(2016A030313611);; 广东省科技计划项目(2014A020212255);; 全军医学科研“十二五”计划课题(CWS12J076)~~
【CateGory Index】: R445.2
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