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Effects of PAF and PAF antagonist WEB2170 on relaxation of vascular endothelium after brief deoxygenation and reoxygenation

Han Yaling, Chen Sicong, Zheng Qinyue, Zhang Guoyuan, Li Shaohua, Wu Zhonggui(Department of Cardiology, Changzheng Hospital,Second Military Medical University, Shanghai, 200003)  
By means of the tension determination of the tension determination of rat thoracic aortic rings,it was found that PAF depressed the acetylcholine (Ach)-induced relaxation of the rings,having undergone 20 min deoxygenation followed by 30 min reoxygenation, to 36.1% of norepinephine (NE) precontraction. And PAF receptor antagonist WEB2170 markedly improved Ach-induced relaxation of the brief deoxygenated and reoxygenated rings to 86.7% of NE precontraction.The results indicate that PAF may be one of the mediators involved in the endothelium relaxation dysfunction related to brief deoxygenation and reoxygenation,and that PAF antagonist WEB2170 has the protective effect on endothelial relaxation function.
【CateGory Index】: R331.32
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